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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 285 - 295 (11page)
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초록· 키워드
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Background: Carotid artery intima medial thickness (IMT), brachial-ankle pulse wave velocity (baPWV), and ankle-brachial index (ABI) are commonly used surrogate markers of subclinical atherosclerosis in patients with type 2 diabetes mellitus (T2DM). The cardio-ankle vascular index (CAVI) is a complement to the baPWV, which is affected by blood pressure. However, it is unclear which marker is the most sensitive predictor of atherosclerotic cardiovascular disease (ASCVD). Methods: This was a retrospective non-interventional study that enrolled 219 patients with T2DM. The correlations among IMT, ABI, and CAVI as well as the relationship of these tests to the 10-year ASCVD risk were also analyzed. Results: Among the 219 patients, 39 (17.8%) had ASCVD. In the non-ASCVD group, CAVI correlated significantly with IMT after adjusting for confounding variables, but ABI was not associated with CAVI or IMT. The analyses after dividing the non-ASCVD group into three subgroups according to the CAVI score (<8, ≥8 and <9, and ≥9) demonstrated the significant increase in the mean IMT, 10-year ASCVD risk and number of metabolic syndrome risk factors, and decrease in the mean ABI in the high- CAVI group. A high CAVI was an independent risk factor in the non-ASCVD group for both a high 10-year ASCVD risk (≥7.5%; odds ratio [OR], 2.42; P<0.001) and atherosclerosis (mean IMT ≥1 mm; OR, 1.53; P=0.007). Conclusion: In Korean patients with T2DM without ASCVD, CAVI was the most sensitive of several surrogate markers for the detection of subclinical atherosclerosis.
목차
등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
Yoon KH / 2006 / Epidemic obesity and type 2 diabetes in Asia / Lancet 368:1681~1688
Chan JC / 2009 / Diabetes in Asia: epidemiology, risk factors, and pathophysiology / JAMA 301:2129~2140
이상열 / 2011 / Prevalence of Chronic Complications in Korean Patients with Type 2 Diabetes Mellitus Based on the Korean National Diabetes Program / Diabetes and Metabolism Journal 35(5):504~512
Ogawa O / 2005 / Arterial stiffness is associated with diabetic retinopathy in type 2 diabetes / Diabetes Res Clin Pract 68:162~166
Meyer C / 2004 / Vascular dysfunction and autonomic neuropathy in type 2 diabetes / Diabet Med 21:746~751
Chan JC / 2009 / Diabetes in Asia: epidemiology, risk factors, and pathophysiology / JAMA 301:2129~2140
이상열 / 2011 / Prevalence of Chronic Complications in Korean Patients with Type 2 Diabetes Mellitus Based on the Korean National Diabetes Program / Diabetes and Metabolism Journal 35(5):504~512
Ogawa O / 2005 / Arterial stiffness is associated with diabetic retinopathy in type 2 diabetes / Diabetes Res Clin Pract 68:162~166
Meyer C / 2004 / Vascular dysfunction and autonomic neuropathy in type 2 diabetes / Diabet Med 21:746~751
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