메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류
인문학
인문학 일반 역사학 철학 종교학 어문학 기타 인문학
사회과학
사회과학 일반 경영학 관광학 교육학 군사학 문헌정보학 법학 사회학 신문방송학 심리과학 정치외교학 지리학 행정학 경제학 무역학 인류학 기타 사회과학
자연과학
자연과학 일반 물리학 생물학 생활과학 수학·통계학 천문학 지구과학 화학 기타 자연과학
공학
공학 일반 건축공학 기계공학 산업공학 재료·에너지공학 전기전자공학 조선해양공학 화학공학 컴퓨터학 기타공학
의약학
의학 일반 간호학 수의학 약학 한의학 기초의학 임상의학 기타 의약학
농수해양학
농수해양학 일반 농학 수산학 식품과학 임학 축산학 해상운송학 기타 농수해양학
예술체육학
예술 일반 디자인 미술 미용 사진 음악학 의상 체육 공연매체예술 기타 예술체육학
복합학
학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

ENG

추천
검색

논문 기본 정보

자료유형
학술저널
저자정보
Ji Min Choi (Department of Internal Medicine Healthcare Research Institute Seoul National University Hospital He) Sang Gyun Kim (Department of Internal Medicine and Liver Research Institute Seoul National University College of M) Hyo-Joon Yang (Department of Internal Medicine Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine) Joo Hyun Lim (Department of Internal Medicine Healthcare Research Institute Seoul National University Hospital He) Nam-Yun Cho (Laboratory of Epigenetics Cancer Research Institute Seoul National University College of Medicine S) Woo Ho Kim (Department of Pathology Seoul National University College of Medicine Seoul Korea) Joo Sung Kim (Department of Internal Medicine Healthcare Research Institute Seoul National University Hospital He) Hyun Chae Jung (Department of Internal Medicine and Liver Research Institute Seoul National University College of M)
저널정보
거트앤리버 발행위원회 Gut and Liver Gut and Liver 제14권 제5호
발행연도
2020.1
수록면
571 - 580 (10page)

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색

초록· 키워드

오류제보하기
Background/Aims: Epigenetic change is one of the mechanisms that regulates the expression of microRNAs (miRNAs) and is known to play a role in Helicobacter pylori-associated gastric carcinogenesis. We aimed to evaluate the epigenetic changes of miR-200a/b in H. pylori-associated gastric carcinogenesis and restoration after eradication. Methods: The expression and methylation levels of miR-200a/b were evaluated in gastric cancer (GC) cell lines, human gastric mucosa of H. pylori-negative and -positive controls, and H. pyloripositive GC patients. Next, the changes in the expression and methylation levels of miR-200a/b were compared between H. pylori -eradication and H. pylori -persistence groups at 6 months. Real-time reverse transcription-polymerase chain reaction was conducted to investigate the miRNA expression levels, and MethyLight was performed to assess the methylation levels. Results: In the GC cell lines, the level of miR- 200a/b methylation decreased and the level of expression increased after demethylation. In the human gastric mucosa, the miR-200a/b methylation levels increased in the following group order: H. pylori-negative control group, H. pylori-positive control group, and H. pylori-positive GC group. Conversely, the miR-200a/b expression levels decreased in the same order. In the H. pylori -persistence group, no significant changes were observed in the methylation and expression levels of miR-200a/b after 6 months, whereas the level of methylation decreased and the level of expression of miR-200a/b increased significantly 6 months in the H. pylori-eradication group. Conclusions: Epigenetic alterations of miR-200a/b may be implicated in H. pylori -induced gastric carcinogenesis. This field defect for cancerization is suggested to be improved by H. pylori eradication.
#Helicobacter pylori #MicroRNAs #Methylation #Epigenetic alteration #Stomach neoplasm

목차

등록된 정보가 없습니다.

참고문헌 (39)

참고문헌 신청
Ferlay J / 2015 / Cancer incidence and mortality worldwide : sources, methods and major patterns in GLOBOCAN 2012 / Int J Cancer 136:E359~E386 google schola Aesun Shin / 2011 / Gastric Cancer Epidemiology in Korea / Journal of Gastric Cancer 11(3):135~140 google schola Correa P / 1992 / Human gastric carcinogenesis : a multistep and multifactorial process : First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention / Cancer Res 52:6735~6740 google schola Ushijima T / 2004 / Focus on gastric cancer / Cancer Cell 5:121~125 google schola Maekita T / 2006 / High levels of aberrant DNA methylation in Helicobacter pylori-infected gastric mucosae and its possible association with gastric cancer risk / Clin Cancer Res 12(3 Pt 1):989~995 google schola

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0