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- 영남대학교 의과대학 Journal of Yeungnam Medical Science Yeungnam University Journal of Medicine 제38권 제2호
- 발행연도
- 2021.1
- 수록면
- 83 - 94 (12page)
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The global obesity epidemic and the growing elderly population largely contribute to the increasing incidence of type 2 diabetes. Insulin resistance acts as a critical link between the present obesity pandemic and type 2 diabetes. Naturally occurring reactive oxygen species (ROS) regulate intracellular signaling and are kept in balance by the antioxidant system. However, the imbalance between ROS production and antioxidant capacity causes ROS accumulation and induces oxidative stress. Oxidative stress interrupts insulin-mediated intracellular signaling pathways, as supported by studies involving genetic modification of antioxidant enzymes in experimental rodents. In addition, a close association between oxidative stress and insulin resistance has been reported in numerous human studies. However, the controversial results with the use of antioxidants in type 2 diabetes raise the question of whether oxidative stress plays a critical role in insulin resistance. In this review article, we discuss the relevance of oxidative stress to insulin resistance based on genetically modified animal models and human trials.
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참고문헌 (99)
참고문헌 신청
Abdali D / 2015 / How effective are antioxidant supplements in obesity and diabetes / Med Princ Pract 24:201~215
Forbes JM / 2013 / Mechanisms of diabetic complications / Physiol Rev 93:137~188
Di Meo S / 2017 / Skeletal muscle insulin resistance : role of mitochondria and other ROS sources / J Endocrinol 233:R15~R42
Facchini FS / 2001 / Insulin resistance as a predictor of age-related diseases / J Clin Endocrinol Metab 86:3574~3578
Rains JL / 2011 / Oxidative stress, insulin signaling, and diabetes / Free Radic Biol Med 50:567~575
Forbes JM / 2013 / Mechanisms of diabetic complications / Physiol Rev 93:137~188
Di Meo S / 2017 / Skeletal muscle insulin resistance : role of mitochondria and other ROS sources / J Endocrinol 233:R15~R42
Facchini FS / 2001 / Insulin resistance as a predictor of age-related diseases / J Clin Endocrinol Metab 86:3574~3578
Rains JL / 2011 / Oxidative stress, insulin signaling, and diabetes / Free Radic Biol Med 50:567~575
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