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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 366 - 366 (1page)
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The improvement of production titers for secondary metabolites requires systematic transcriptional optimization of genes involved in their biosynthesis. Here, we describe the use of synthetic biology approach for titer improvement of clinically important antibiotic daptomycin. The transcriptome analysis of daptomycin producer Streptomyces roseosporus NRRL 11379 revealed that poor transcriptions of genes in daptomycin BGC (biosynthetic gene cluster) are the major cause of low production titer. To optimize the transcriptions of genes, we gene ... 전체 초록 보기
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Stepwise engineering of biosynthetic gene cluster for titer improvement of clinically important antibiotic daptomycin in Streptomyces roseosporus
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