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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 76 - 76 (1page)
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Titer improvements of secondary metabolites using synthetic biology approach has been technically challenging if BGCs (biosynthetic gene clusters) contain large-size genes of multi-modular enzymes such as NRPS (non-ribosomal peptide synthetase) and PKS (polyketide synthase) due to the difficulty of gene synthesis. In such a case, top-down approach provides a viable alternative in which BGCs could be rationally engineered with the minimum input of synthetic DNAs. We successfully implemented this strategy for titer improvements of clinically important antibiotic daptomycin through stepwise tr ... 전체 초록 보기
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