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논문 기본 정보

자료유형
학술저널
저자정보
Norifumi Fujii (Department of Rehabilitation Shimura Hospital Hiroshima Japan) Manabu Tsukamoto (Dept. of Orthopedic Surgery University of Occupational and Environmental Health Japan) Nobukazu Okimoto (Okimoto Clinic / Department of Orthopedic Surgery Shimura Hospital Hiroshima Japan) Miyuki Mori (Department of Radiology Shimura Hospital Hiroshima Japan) Yoshiaki Ikejiri (Department of Orthopedic Surgery Shimura Hospital Hiroshima Japan) Toru Yoshioka (Department of Orthopedic Surgery Shimura Hospital Hiroshima Japan) Makoto Kawasaki (Dept. of Orthopedic Surgery University of Occupational and Environmental Health Japan) Nobuhiro Kito (Department of Rehabilitation Hiroshima International University Hiroshima Japan) Junya Ozawa (Department of Rehabilitation Hiroshima International University Hiroshima Japan) Ryoichi Nakamura (Department of Rehabilitation Shimura Hospital Hiroshima Japan) Shogo Takano (Department of Rehabilitation Shimura Hospital Hiroshima Japan) Saeko Fujiwara (Department of Pharmacy Yasuda Women's University Hiroshima Japan)
저널정보
대한골다공증학회 Osteoporosis and Sarcopenia Osteoporosis and Sarcopenia Vol.7 No.2
발행연도
2021.1
수록면
54 - 62 (9page)

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Objectives: The relationship between weight-related load and bone mineral density (BMD)/bone microstructure under normal load conditions using high-resolution peripheral quantitative computed tomography (HR-pQCT) remains unconfirmed. The study aims to investigate the differences in effect of body mass index (BMI) on BMD/bone microstructure of loaded and unloaded bones, respectively, in Japanese postmenopausal women. Methods: Fifty-seven postmenopausal women underwent HR-pQCT on the tibia and radius. Correlation analysis, principal component (PC) analysis, and hierarchical multiple regression were performed to examine the relationship between BMI and HR-pQCT parameters. Results: Several microstructural parameters of the tibia and radius correlated with BMI through a simple correlation analysis, and these relationships remained unchanged even with an age-adjusted partial correlation analysis. PC analysis was conducted using seven bone microstructure parameters. The first PC (PC1) reflected all parameters of trabecular and cortical bone microstructures, except for cortical porosity, whereas the second PC (PC2) reflected only cortical bone microstructure. Hierarchical multiple regression analysis indicated that BMI was more strongly related to BMD/bone microstructure in the tibia than in the radius. Furthermore, BMI was associated with trabecular/cortical BMD, and PC1 (not PC2) of the tibia and radius. Thus, BMI was strongly related to the trabecular bone microstructure rather than the cortical bone microstructure. Conclusions: Our data confirmed that BMI is associated with volumetric BMD and trabecular bone microstructure parameters in the tibia and radius. However, although BMI may be more related to HRpQCT parameters in the tibia than in the radius, the magnitude of association is modest.
#Bone mineral density #Body mass index #High-resolution peripheral quantitative computed tomography #Osteoporosis #Loaded bone

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참고문헌 (36)

참고문헌 신청
Friedman AW / 2006 / Important determinants of bone strength : beyond bone mineral density / J Clin Rheumatol 12:70~77 google schola Arita S / 2004 / Human parathyroid hormone (1-34) increases mass and structure of the cortical shell, with resultant increase in lumbar bone strength, in ovariectomized rats / J Bone Miner Metabol 22:530~540 google schola Taketa T / 2008 / Selective cyclooxygenase-2 inhibitor prevents reduction of trabecular bone mass in collagen-induced arthritic mice in association with suppression of RANKL/OPG ratio and IL-6 mRNA expression in synovial tissues but not in bone marrow cells / J Bone Miner Metabol 26:143~151 google schola Tsukamoto M / 2016 / Elcatonin prevents bone loss caused by skeletal unloading by inhibiting preosteoclast fusion through the unloading-induced high expression of calcitonin receptors in bone marrow cells / Bone 85:70~80 google schola Menuki K / 2008 / Climbing exercise enhances osteoblast differentiation and inhibits adipogenic differentiation with high expression of PTH/PTHrP receptor in bone marrow cells / Bone 43:613~620 google schola

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