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논문 기본 정보

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학술저널
저자정보
Rundong Qin (The First Affiliated Hospital of Guangzhou Medical University) Fei Long (Guangzhou Medical University) Xiaojun Xiao (The First Affiliated Hospital of Guangzhou Medical University) Jing Xiao (Guangzhou Medical University) Zhengyu Zheng (The First Affiliated Hospital of Guangzhou Medical University) Mulin Feng (The First Affiliated Hospital of Guangzhou Medical University) Renbin Huang (The First Affiliated Hospital of Guangzhou Medical University) Tao Peng (Guangzhou Medical University) Jing Li (The First Affiliated Hospital of Guangzhou Medical University)
저널정보
대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.11 No.3
발행연도
2019.1
수록면
406 - 421 (16page)

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Purpose: The data on the differences between sputum autoantibodies (Sp-Abs) and serum autoantibodies (Se-Abs) in reflection of autoimmune responses to lungs is still lacking. Methods: Ten types of Abs were investigated in matched Se and Sp samples collected from recruited subjects. Correlations between Ab levels and airway inflammatory parameters and measures of pulmonary function were assessed. The network-based and inter-correlated analysis was performed to explore the patterns of Sp- and Se-Ab profiles. Results: Fifty stable asthmatic patients and 24 healthy volunteers were recruited for our study, 15 with mild asthma, 18 with moderate asthma and 17 with severe asthma. The concentrations of Sp-Ab against U1 small nuclear ribonucleoprotein (Sp-anti-U1-SnRNP), Sp-Ab against Smith antigen and Se-Ab against thyroid peroxidase (anti-TPO) in severe asthmatics and Sp-anti-U1-SnRNP in moderate asthmatics were significantly higher compared to healthy controls and mild asthmatic subjects (P < 0.05). Sp-anti-U1-SnRNP levels were positively correlated with the dose of inhaled corticosteroids, Sp eosinophil counts and fractional exhaled nitric oxide (r = 0.326, P = 0.022; r = 0.356, P = 0.012; r = 0.241, P = 0.025, respectively) and negatively correlated with Sp neutrophil counts (r = −0.308, P = 0.031) with adjustment for age. Spearman's correlation matrix showed multiple inter-correlations among Sp-Abs and Se-Abs (P < 0.05) while only the levels of Ab against DNA topoisomerase and anti-TPO in Se were correlated with those Sp-Ab counterparts (P < 0.05). The network-based analysis defined 2 clusters: clusters 1 and 2 contained 10 Sp-Abs and 10 Se-Abs, respectively. Conclusions: This study observes that Sp-Abs are more associated with clinical parameters and the severity of disease in asthma compared to Se-Abs. Targeting on Sp-Abs which are the hallmark of the localized autoimmune event might help us better understand the role of autoimmunity in the pathological mechanism of asthma. Keywords: Asthma; autoimmunity; autoantibodies; sputum; se
#Asthma #autoimmunity #autoantibodies #sputum #serum

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참고문헌 (40)

참고문헌 신청
Stene LC / 2001 / Relation between occurrence of type 1 diabetes and asthma / Lancet 357:607~608 google schola Tedeschi A / 2001 / Common risk factors in type 1 diabetes and asthma / Lancet 357:1622 google schola Tedeschi A / 2006 / Is affluence a risk factor for bronchial asthma and type 1 diabetes / Pediatr Allergy Immunol 17:533~537 google schola Sheikh A / 2003 / There is no evidence of an inverse relationship between TH2-mediated atopy and TH1-mediated autoimmune disorders : lack of support for the hygiene hypothesis / J Allergy Clin Immunol 111:131~135 google schola Kero J / 2001 / Could TH1 and TH2 diseases coexist? Evaluation of asthma incidence in children with coeliac disease, type 1 diabetes, or rheumatoid arthritis : a register study / J Allergy Clin Immunol 108:781~783 google schola

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