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논문 기본 정보

자료유형
학술저널
저자정보
SooHyun Bae (Ulsan University Hospital) Minkyu Han (Asan Medical Center University of Ulsan College of Medicine) Changyoung Kim (Medical Information Center of Ulsan University Hospital) Hyeji Lee (Department of Emergency Medicine Ulsan University Hospital) 안종준 (울산대학교) 김진형 (Asan Medical Center University of Ulsan College of Medicine) Byung Ju Kang (Department of Internal Medicine Ulsan University Hospital)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.35 No.10
발행연도
2020.1
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1 - 16 (16page)

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Background: Usually, high-flow nasal cannula (HFNC) therapy is indicated for de novo acute hypoxemic respiratory failure (AHRF). Although only a few researches have examined the effectiveness of HFNC therapy for respiratory failure with hypercapnia, this therapy is often performed under such conditions for various reasons. We investigated the effectiveness of HFNC therapy for AHRF patients with hypercapnia compared to those without hypercapnia. Methods: All consecutive patients receiving HFNC therapy between January 2012 and June 2018 at a university hospital were enrolled and classified into nonhypercapnic and hypercapnic groups. We compared the outcomes of both groups and adjusted the outcomes with propensity score matching. Results: A total of 862 patients were enrolled, of which 202 were included in the hypercapnic group. HFNC weaning success rates were higher, and intensive care unit (ICU) and hospital mortality was lower in the hypercapnic group than in the nonhypercapnic group (all P < 0.05). However, no statistical differences in HFNC weaning success (adjusted P = 0.623, matched P = 0.593), ICU mortality (adjusted P = 0.463, matched P = 0.195), and hospital mortality (adjusted P = 0.602, matched P = 0.579) were noted from the propensity- adjusted and propensity-matched analyses. Additionally, in the propensity score-matched subgroup analysis (according to chronic lung diseases and causes of HFNC application), there was also no significant difference in outcomes between the two groups. Conclusion: In AHRF with underlying conditions, HFNC therapy might be helpful for patients with hypercapnia. Large prospective and randomized controlled trials are required for firm conclusions.
#Oxygen Inhalation Therapy #Respiratory Insufficiency #Noninvasive Ventilation #Hypercapnia #Propensity Score

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참고문헌 (30)

참고문헌 신청
Ou X / 2017 / Effect of high-flow nasal cannula oxygen therapy in adults with acute hypoxemic respiratory failure : a meta-analysis of randomized controlled trials / CMAJ 189(7):E260~E267 google schola Frat JP / 2015 / High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure / N Engl J Med 372(23):2185~2196 google schola Rochwerg B / 2019 / High flow nasal cannula compared with conventional oxygen therapy for acute hypoxemic respiratory failure: a systematic review and metaanalysis / Intensive Care Med 45(5):563~572 google schola 유정완 / 2016 / Clinical efficacy of high-flow nasal cannula compared to noninvasive ventilation in patients with post-extubation respiratory failure / The Korean Journal of Internal Medicine 31(1):82~88 Crossref 김현주 / 2019 / High-flow nasal oxygenation for anesthetic management / Korean Journal of Anesthesiology 72(6):527~547 dbpia

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