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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 893 - 899 (7page)
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초록· 키워드
오류제보하기
Background Litter size is the most important reproductive trait which plays a crucial role in goat production. Therefore, improvement of litter size trait has been of increasing interest in goat industry as small improvement in litter size may lead to large profit. The recent Cashmere goat breeding program produced a high-reproductive genetic line of Arbas Cashmere goat. But the genetic mechanism of high reproduction rate remains largely unknown in this Chinese native goat breed. To address this question, we performed a genome-wide association studies (GWAS) using two groups of goats varying in fecundity. Objectives Our study was aimed to investigate the significant SNPs and genes associated with high reproduction trait in Inner Mongolia Arbas Cashmere Goat. Methods We used logistic model association to perform GWAS using 47 goats from high fecundity group (~ 190%) and 314 goats from low fecundity group (~ 130%) of the Arbas Cashmere goat breed. Results We identified 66 genomic regions associated with genome wide significant level wherein six loci were found to be associated with reproduction traits. Further analysis showed that five key candidate genes including KISS1, KHDRBS2, WNT10B, SETDB2 and PPP3CA genes are involved in goat fecundity trait. Gene ontology enrichment analysis revealed that several biological pathways could be involved in the variation of fecundity in female goats. Conclusions The identified significant SNPs or genes provide useful information about the underlying genetic control of fecundity trait which will be helpful to use them in goat breeding programs for improving the reproductive efficiency of goats.
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참고문헌 (29)
참고문헌 신청
Cao GL / 2010 / Analysis on DNA sequence of KiSS-1 gene and its association with litter size in goats / Mol Biol Rep 37:3921~3929
Devendra C / 2015 / Dynamics of goat meat production in extensive systems in Asia : improvement of productivity and transformation of livelihoods / Agrotechnology 4:131~141
Fan H-Y / 2012 / Consequences of RAS and MAPK activation in the ovary : the good, the bad and the ugly / Mol Cell Endocrinol 356:74~79
FAO / FAO Statistics
Guan D / 2016 / Scanning of selection signature provides a glimpse into important economic traits in goats(Capra hircus) / Sci Rep 6:36372
Devendra C / 2015 / Dynamics of goat meat production in extensive systems in Asia : improvement of productivity and transformation of livelihoods / Agrotechnology 4:131~141
Fan H-Y / 2012 / Consequences of RAS and MAPK activation in the ovary : the good, the bad and the ugly / Mol Cell Endocrinol 356:74~79
FAO / FAO Statistics
Guan D / 2016 / Scanning of selection signature provides a glimpse into important economic traits in goats(Capra hircus) / Sci Rep 6:36372
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