지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 398 - 405 (8page)
이용수
초록· 키워드
오류제보하기
Background: To evaluate the changes in cardiovascular risk markers including pulse wave velocity (PWV), microalbuminuria, inflammatory cytokines, and adhesion molecules after treatment with beraprost sodium (BPS) in patients with diabetic nephropathyMethods: This was a multicenter, prospective, randomized, double-blind, placebo-controlled trial. Type 2 diabetes mellitus patientswith microalbuminuria were included. The primary endpoints were changes in microalbuminuria in spot urine and PWV after BPSor placebo (PCB) treatment for 24 weeks. The secondary endpoints were changes in clinical and metabolic parameters. Results: A total of 52 patients completed the 24-week trial. Changes in PWV were not different significantly in the BPS and PCBgroups (right, P=0.16; left, P=0.11). Changes in microalbuminuria were 14.2±157.0 and 34.5±146.6 (μg/mg Cr) in the BPS andPCB groups, respectively (P=0.63). Subgroup analysis in the high blood pressure (BP) group (baseline systolic BP >120 mm Hgand diastolic BP >80 mm Hg), showed that microalbuminuria decreased by –47.6 in the BPS group compared with an increase by116.4 (μg/mg Cr) in the PCB group (P=0.04). Also, in the large waist circumference group (>95 cm), microalbuminuria decreasedsignificantly in the BPS group (P=0.04). Conclusion: Short-term treatment of BPS for patients with diabetic nephropathy did not show significant improvement in variouscardiovascular risk factors. However, BPS significantly decreased microalbuminuria in study subjects with higher cardiovascularrisk such as high BP or large waist circumference
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Melian EB / 2002 / Beraprost : a review of its pharmacology and therapeutic efficacy in the treatment of peripheral arterial disease and pulmonary arterial hypertension / Drugs 62:107~133
Goya K / 2003 / Effects of the prostaglandin I2 analogue, beraprost sodium, on vascular cell adhesion molecule-1 expression in human vascular endothelial cells and circulating vascular cell adhesion molecule-1level in patients with type 2 diabetes mellitus / Metabolism 52:192~198
Shin S / 2013 / The effect of oral prostaglandin analogue on painful diabetic neuropathy: a double-blind, randomized, controlled trial / Diabetes Obes Metab 15:185~188
Guan J / 2014 / Effects of beraprost sodium on renal function and inflammatory factors of rats with diabetic nephropathy / Genet Mol Res 13:4154~4158
Watanabe M / 2009 / Amelioration of diabetic nephropathy in OLETF rats by prostaglandin I(2) analog, beraprost sodium / Am J Nephrol 30:1~11
Goya K / 2003 / Effects of the prostaglandin I2 analogue, beraprost sodium, on vascular cell adhesion molecule-1 expression in human vascular endothelial cells and circulating vascular cell adhesion molecule-1level in patients with type 2 diabetes mellitus / Metabolism 52:192~198
Shin S / 2013 / The effect of oral prostaglandin analogue on painful diabetic neuropathy: a double-blind, randomized, controlled trial / Diabetes Obes Metab 15:185~188
Guan J / 2014 / Effects of beraprost sodium on renal function and inflammatory factors of rats with diabetic nephropathy / Genet Mol Res 13:4154~4158
Watanabe M / 2009 / Amelioration of diabetic nephropathy in OLETF rats by prostaglandin I(2) analog, beraprost sodium / Am J Nephrol 30:1~11
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
2018 Korean Society of Hypertension Guidelines for the management of hypertension: part II-diagnosis and treatment of hypertension
Clinical Hypertension
2019 .01
-
Association between Body Mass Index, Waist Circumference and Prevalence of Microalbuminuria in Korean Adults of Age 30 Years and Older without Diabetes, Hypertension, Renal Failure, or Overt Proteinuria: The 2013 Korean National Health and Nutrition Examination Survey
Korean Journal of Family Medicine
2016 .01
-
Association between shift work and microalbuminuria : data from KNHANES(2012–2014)
대한직업환경의학회지
2017 .09
-
Which blood pressure metrics should be used in patients on dialysis?
Kidney Research and Clinical Practice
2024 .03
-
Characteristics of patients with osteonecrosis of the jaw with oral versus intravenous bisphosphonate treatment
Maxillofacial Plastic Reconstructive Surgery
2021 .12
-
The compatibility of new blood pressure reference values for Korean children and adolescents with the US reference: the Korean Working Group of Pediatric Hypertension
Clinical Hypertension
2022 .01
-
Fimasartan-Based Blood Pressure Control after Acute Cerebral Ischemia: The Fimasartan-Based Blood Pressure Control after Acute Cerebral Ischemia Study
Journal of Clinical Neurology
2021 .01
-
Erratum to: Relationship between nocturnal blood pressure and 24-h urinary sodium excretion in a rural population in Korea
Clinical Hypertension
2015 .01
-
Intensive blood pressure lowering: a practical review
Clinical Hypertension
2021 .01
-
A clinical algorithm to determine target blood pressure in the elderly: evidence and limitations from a clinical perspective
Clinical Hypertension
2022 .01
-
The 2022 focused update of the 2018 Korean Hypertension Society Guidelines for the management of hypertension
Clinical Hypertension
2023 .01
-
Effect of Preoperative Bisphosphonate Treatment on Fracture Healing after Internal Fixation Treatment of Intertrochanteric Femoral Fractures
Hip and Pelvis
2019 .01
-
Automated Office Blood Pressure Measurement
Korean Circulation Journal
2018 .01
-
Clinical Significance and Therapeutic Implication of Nocturnal Hypertension: Relationship between Nighttime Blood Pressure and Quality of Sleep
Korean Circulation Journal
2019 .01
-
RESEARCH Open Access Relationship between uric acid and blood pressure in different age groups
Clinical Hypertension
2015 .01
-
Differences in Psychopathology between Offspring of Parents with Bipolar I Disorder and Those with Bipolar II Disorder: A Cross-Sectional Study
PSYCHIATRY INVESTIGATION
2018 .01
-
Regression and progression of microalbuminuria in adolescents with childhood onset diabetes mellitus
Annals of Pediatirc Endocrinology & Metabolism
2015 .01
-
Effects of Age on Arterial Stiffness and Blood Pressure Variables in Patients with Newly Diagnosed Untreated Hypertension
Korean Circulation Journal
2015 .01
-
Physician perceptions of blood pressure control in patients with chronic kidney disease and target blood pressure achievement rate
Kidney Research and Clinical Practice
2017 .01
-
Hypertension Management in Patients with Chronic Kidney Disease in the Post-SPRINT Era
Electrolytes & Blood Pressure
2021 .12
이 논문의 저자 정보
최근 본 자료
댓글(0)
0