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논문 기본 정보

자료유형
학술저널
저자정보
Chebotareva Natalia (Sechenov First Moscow State Medical University Moscow Russia) Berns Svetlana (Zhadkevich City Clinical Hospital Moscow Russia) Berns Angelina (Sechenov First Moscow State Medical University Moscow Russia) Androsova Tatyana (Sechenov First Moscow State Medical University Moscow Russia) Lebedeva Marina (Sechenov First Moscow State Medical University Moscow Russia) Moiseev Sergey (Sechenov First Moscow State Medical University Moscow Russia)
저널정보
대한신장학회 Kidney Research and Clinical Practice Kidney Research and Clinical Practice Vol.40 No.2
발행연도
2021.1
수록면
241 - 249 (9page)

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Background: The development of acute kidney injury (AKI) in patients with coronavirus disease 2019 (COVID-19) is associated with a high risk of death. Published data demonstrate the possibility of severe kidney injury in patients suffering from COVID-19. However, these data are still controversial. Methods: A total of 1,280 patients with a proven diagnosis of COVID-19 were included in our study. COVID-19 was confirmed in all patients using reverse transcriptase polymerase chain reaction test of a nasopharyngeal swab, and based on the typical computed tomography findings. Demographic data, underlying comorbidities, and laboratory blood tests were assessed. We assessed the incidence of AKI and its associated mortality defined by survival status at discharge. Results: Proteinuria was identified with 648 patients (50.6%) with COVID-19. AKI was identified in 371 patients (29.0%). Ten of these patients (2.7%) required dialysis. The risk factors for AKI included age of > 65 years, augmentation of C-reactive protein, ferritin and an increase in values of activated partial thromboplastin time. Overall, 162 of the 1,280 hospitalized patients (12.7%) and 111 of the 371 patients (29.9%) with AKI did not survive. The hazard ratio (HR) for mortality was 3.96 (95% confidence interval, 2.83–5.54) for patients with AKI vs. no AKI. Conclusion: AKI was a relatively common finding among patients with COVID-19. The risk factors for AKI in COVID-19 included old age, the inflammatory response, the severity of lung involvement, and disseminated intravascular coagulation. These same factors, in addition to arterial hypertension, were found to increase the risk of mortality.
#Acute kidney injury #COVID-19 #Hematuria #Mortality #Proteinuria

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참고문헌 (25)

참고문헌 신청
Wang D / 2020 / Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China / JAMA 323:1061~1069 google schola Guan WJ / 2020 / Clinical characteristics of coronavi"rus disease 2019 in China / N Engl J Med 382:1708~1720 google schola Li Z / 2020 / Caution on kidney dysfunctions of COVID-19 patients / medRxiv Crossref Wang L / 2020 / Coronavirus disease 19 infection does not result in acute kidney injury : an analysis of 116 hospitalized patients from Wuhan, China / Am J Nephrol 51:343~348 google schola Yang X / 2020 / Clinical course and outcomes of critical"ly ill patients with SARS-CoV-2 pneumonia in Wuhan, China : a single-centered, retrospective, observational study / Lancet Respir Med 8:475~481 google schola

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