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논문 기본 정보

자료유형
학술저널
저자정보
Komaru Yohei (The University of Tokyo Hospital Tokyo Japan) Doi Kent (The University of Tokyo Hospital Tokyo Japan)
저널정보
대한신장학회 Kidney Research and Clinical Practice Kidney Research and Clinical Practice Vol.40 No.2
발행연도
2021.1
수록면
177 - 179 (3page)

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초록· 키워드

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Acute kidney injury (AKI) is one of the most frequent complications in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during the coronavirus disease 2019 (COVID-19) pandemic. Although COVID-19 is characterized by atypical pneumonia and subsequent severe respiratory failure, approximately 10% of inpatients with COVID-19 reportedly suffer from AKI [1], which is significantly associated with poor outcomes [2]. Successive recent publications have reported an even higher global incidence of AKI. Patients with COVID-19 who are being treated in intensive care units (ICUs) are the most susceptible to severe AKI, which requires renal replacement therapy. However, the pathophysiology of COVID-19-associated AKI remains to be determined; systemic inflammation, hypovolemia, nephrotoxic drugs, various lung-kidney interactions (such as possible renal congestion presumably caused by high levels of positive end expiratory pressure), and direct viral cytopathic effects on the renal epithelium and podocytes are all possible mechanisms currently in discussion [3]. With no specific treatment for COVID-19-associated AKI available, early recognition of patients at risk and early diagnosis of AKI are key to confronting this emerging health burden on clinical nephrology.

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