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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.11
- 수록면
- 308 - 316 (9page)
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초록· 키워드
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Background: The kidney represents a potential target for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Clinical data about acute kidney injury (AKI) during SARS-CoV-2 infection are lacking. We aimed to investigate the proportion, risk factors, and prognosis of AKI in critical patients affected with SARS-CoV-2.
Methods: A case/control study was conducted in two intensive care units of a tertiary teaching hospital.
Results: Among 109 patients, 75 were male (69%) with median age at 64 years and 48 (44%) developed AKI within 4 days (interquartile range [IQR], 1?9). Of them, 11 (23%), 9 (19%), and 28 (58%) were classified as stage 1, 2, and 3, respectively. AKI patients were older and presented more sepsis, acute respiratory distress syndrome, and rhabdomyolysis; higher initial urea and cre atinine; more marked inflammatory syndrome and hematological disorders; and required more mechanical ventilation and vasopressors. An elevated D-dimers level (odds ratio [OR], 12.83; 95% confidence interval [CI], 1.9?85) was an independent factor of AKI. Sepsis was near to signifi cance (OR, 5.22; 95% CI, 0.94?28; P=0.058). AKI was independently related to mortality (OR, 6.8; 95% CI, 1.49?105) and significantly reduced the survival (14.7 days; IQR, 12-17 vs. 19.9 days; IQR, 17-22.7; P=0.011) in AKI and no AKI group respectively. Hypoxemia with the ratio of the ar terial partial pressure of oxygen and the inspiratory concentration of oxygen <70, and vasopres sors were identified as mortality factors.
Conclusions: AKI occurred in almost half the studied patients and significantly worsened their prognosis. A high D-dimers level and sepsis contributed significantly to its development.
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참고문헌 (29)
참고문헌 신청
White-Dzuro G / 2021 / Multisystem effects of COVID-19 : a concise review for practitioners / Postgrad Med 133:20~27
Grasselli G / 2020 / Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy region, Italy / JAMA 323:1574~1581
Guan WJ / 2020 / Clinical characteristics of coronavirus disease 2019 in China / N Engl J Med 382:1708~1720
Richardson S / 2020 / Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York city area / JAMA 323:2052~2059
Xie J / 2020 / Clinical characteristics and outcomes of critically ill patients with novel coronavirus infectious disease(COVID-19)in China : a retrospective multicenter study / Intensive Care Med 46:1863~1872
Grasselli G / 2020 / Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy region, Italy / JAMA 323:1574~1581
Guan WJ / 2020 / Clinical characteristics of coronavirus disease 2019 in China / N Engl J Med 382:1708~1720
Richardson S / 2020 / Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York city area / JAMA 323:2052~2059
Xie J / 2020 / Clinical characteristics and outcomes of critically ill patients with novel coronavirus infectious disease(COVID-19)in China : a retrospective multicenter study / Intensive Care Med 46:1863~1872
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