지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 362 - 375 (14page)
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초록· 키워드
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Chronic traumatic encephalopathy (CTE) is a distinct neurodegenerative disease that associated with repetitive head trauma. CTE is neuropathologically defined by the perivascular accumulation of abnormally phosphorylated tau protein in the depths of the sulci in the cerebral cortices. In advanced CTE, hyperphosphorylated tau protein deposits are found in widespread regions of brain, however the mechanisms of the progressive neurodegeneration in CTE are not fully understood. In order to identify which proteomic signatures are associated with CTE, we prepared RIPA-soluble fractions and performed quantitative proteomic analysis of postmortem brain tissue from individuals neuropathologically diagnosed with CTE. We found that axonal guidance signaling pathwayrelated proteins were most significantly decreased in CTE. Immunohistochemistry and Western blot analysis showed that axonal signaling pathway-related proteins were down regulated in neurons and oligodendrocytes and neuron-specific cytoskeletal proteins such as TUBB3 and CFL1 were reduced in the neuropils and cell body in CTE. Moreover, oligodendrocyte-specific proteins such as MAG and TUBB4 were decreased in the neuropils in both gray matter and white matter in CTE, which correlated with the degree of axonal injury and degeneration. Our findings indicate that deregulation of axonal guidance proteins in neurons and oligodendrocytes is associated with the neuropathology in CTE. Together, altered axonal guidance proteins may be potential pathological markers for CTE.
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참고문헌 (61)
참고문헌 신청
Thunnan DJ / 1998 / The epidemiology of sports-related traumatic brain injuries in the United States : recent developments / J Head Trauma Rehabil 13:1~8
Langlois JA / 2006 / The epidemiology and impact of traumatic brain injury : a brief overview / J Head Trauma Rehabil 21:375~378
Finkelstein E / 2006 / The incidence and economic burden of injuries in the United States / Oxford University Press
Graves AB / 1990 / The association between head trauma and Alzheimer's disease / Am J Epidemiol 131:491~501
Mortimer JA / 1985 / Head injury as a risk factor for Alzheimer's disease / Neurology 35:264~267
Langlois JA / 2006 / The epidemiology and impact of traumatic brain injury : a brief overview / J Head Trauma Rehabil 21:375~378
Finkelstein E / 2006 / The incidence and economic burden of injuries in the United States / Oxford University Press
Graves AB / 1990 / The association between head trauma and Alzheimer's disease / Am J Epidemiol 131:491~501
Mortimer JA / 1985 / Head injury as a risk factor for Alzheimer's disease / Neurology 35:264~267
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