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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한노인병학회 Annals of geriatric medicine and research Annals of geriatric medicine and research Vol.25 No.1
- 발행연도
- 2021.1
- 수록면
- 4 - 9 (6page)
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초록· 키워드
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Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in a global pandemic and significant loss of life. Older people are vulnerable to SARS-CoV-2 infections and complications; thus, they are a priority group to receive COVID-19 vaccines. This review discusses considerations for COVID-19 vaccines for older adults. The general concepts of vaccine effectiveness in older adults are described, particularly immune senescence and vaccine development approaches to improve immunogenicity. The types of COVID-19 vaccine platforms are also described before reviewing the available, although limited, evidence from phase 3 COVID-19 vaccine trials relevant to older adults. The BNT162b2 vaccine by Pfizer-BioNTech and mRNA-1273 vaccine from Moderna demonstrated high efficacy and immunogenicity, which were also observed in older people. While the ChAdOx1 nCoV-19 vaccine (AZD1222) by AstraZeneca demonstrated some efficacy in older people, the vaccine dose requires clarification through further studies. Finally, the Ad26.COV2.S vaccine by Janssen Pharmaceuticals shows promise as a single-dose vaccine with a potential durability of response.
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참고문헌 (25)
참고문헌 신청
World Health Organization / The COVID-19 candidate vaccine landscape
US Food and Drug Administration / COVID-19 vaccines
World Health Organization / WHO SAGE Roadmap for prioritizing uses of COVID-19 vaccines in the context of limited supply
Krause P / 2020 / COVID-19 vaccine trials should seek worthwhile efficacy / Lancet 396:741~743
McElhaney JE / 2016 / T-cell immunity to influenza in older adults : a pathophysiological framework for development of more effective vaccines / Front Immunol 7:41
US Food and Drug Administration / COVID-19 vaccines
World Health Organization / WHO SAGE Roadmap for prioritizing uses of COVID-19 vaccines in the context of limited supply
Krause P / 2020 / COVID-19 vaccine trials should seek worthwhile efficacy / Lancet 396:741~743
McElhaney JE / 2016 / T-cell immunity to influenza in older adults : a pathophysiological framework for development of more effective vaccines / Front Immunol 7:41
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