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논문 기본 정보

자료유형
학술저널
저자정보
Yoshimasa Hoshikawa (Barts and the London School of Medicine and Dentistry Queen Mary University of London UK) Akinari Sawada (Barts and the London School of Medicine and Dentistry Queen Mary University of London UK) Shirley Sonmez (Barts and the London School of Medicine and Dentistry Queen Mary University of London UK) Kornilia Nikaki (Barts and the London School of Medicine and Dentistry Queen Mary University of London UK) Philip Woodland (Barts and the London School of Medicine and Dentistry Queen Mary University of London UK) Etsuro Yazaki (Barts and the London School of Medicine and Dentistry Queen Mary University of London UK) Daniel Sifrim (Barts and The London School of Medicine and Dentistry Queen Mary University of London London UK)
저널정보
대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.26 No.2
발행연도
2020.1
수록면
241 - 247 (7page)

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Background/AimsMean nocturnal baseline impedance (MNBI) during multichannel intraluminal impedance pH-monitoring (MII-pH) reflects the status of esophageal mucosal integrity. MNBI is suggested as an adjunctive method to distinguish patients with true gastroesophageal reflux disease (GERD) from functional heartburn (FH) and might predict outcomes for anti-reflux treatment. However, current methodology for calculation of MNBI is time-consuming and subject to operator-dependent selection bias. We aim to simplify and provide a more objective method to calculate MNBI. MethodsWe retrospectively analyzed 100 MII-pH tracings from 20 patients with erosive reflux disease, 20 with non-erosive reflux disease (NERD), 20 with reflux hypersensitivity, 20 with functional heartburn (FH), and 20 healthy asymptomatic volunteers. We compared the current “conventional” MNBI analysis with our “simple” MNBI analysis measured by selecting the whole supine period using the impedance average calculation function in the MII-pH software. ResultsAbsolute values were very similar and there was a strong correlation between conventional and simple MNBI values in the most distal channel in all groups (r ≥ 0.8, P < 0.001) including patients with increased supine acid reflux. Distal esophageal simple MNBI negatively correlated with acid exposure time (r = –0.695, P < 0.001). Patients with erosive reflux disease and NERD had lower simple MNBI values in the most distal channel compared to other groups (P < 0.001). With a cutoff value of 1785 ohms, simple MNBI can discriminate patients with GERD from those with reflux hypersensitivity and FH (sensitivity 80.0% and specificity 89.7%). ConclusionSimple MNBI analysis provides very similar values and has an excellent correlation with conventional MNBI analysis.

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