지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.26 No.3
- 발행연도
- 2020.1
- 수록면
- 362 - 369 (8page)
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Background/AimsWe aimed to evaluate associations between comorbidities, peripheral neuropathy, and spontaneous internal anal sphincter relaxation (SAR) in patients with defecatory disorders. MethodsA patient was considered to exhibit SAR during high-resolution anorectal manometry (HR-ARM) when the nadir pressure is < 15 mmHg and the time from onset to relaxation was ≥ 15 seconds in the resting pressure frame. A case-control study was performed using HR-ARM data collected from 880 patients from January 2010 to May 2015. We identified 23 cases with SAR (median age 75 years; 15 females; 12 fecal incontinence and 11 constipation). We compared HR-ARM values, Charlson index comorbidity scores, neuropathy, and the prevalence of diseases that potentially cause neuropathy between controls and SAR patients. Each SAR case was compared to 3 controls. Controls were selected to match the age, gender, and examination year of each SAR case. ResultsCompared to controls (26.1%), SAR patients (52.2%) exhibited a significantly higher frequency of fecal incontinence. SAR patients also had higher Charlson index scores (5 vs 4, P = 0.028). Nine of 23 SAR patients (39.1%) exhibited peripheral neuropathy— this frequency was higher than that for the control group (11.6%; P = 0.003). Diseases that potentially cause neuropathy were observed in 17 of 23 SAR cases and 32 of 69 controls (P = 0.022). ConclusionsSAR develops in patients with constipation and fecal incontinence but is more common in patients with fecal incontinence. Our controlled observational study implies that SAR is associated with peripheral neuropathy and more severe comorbidities.
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참고문헌 (23)
참고문헌 신청
이태희 / 2016 / How to Perform and Interpret a High-resolution Anorectal Manometry Test / Journal of Neurogastroenterology and Motility (JNM) 22(1):46~59
Rattan S / 2005 / The internal anal sphincter : regulation of smooth muscle tone and relaxation / Neurogastroenterol Motil 17(suppl 1):50~59
Kumar L / 2017 / Internal anal sphincter : clinical perspective / Surgeon 15:211~226
Cobine CA / 2017 / ANO1 in intramuscular interstitial cells of Cajal plays a key role in the generation of slow waves and tone in the internal anal sphincter / J Physiol 595:2021~2041
Kathleen D Keef / 2019 / Control of Motility in the Internal Anal Sphincter / Journal of Neurogastroenterology and Motility (JNM) 25(2):189~204
Rattan S / 2005 / The internal anal sphincter : regulation of smooth muscle tone and relaxation / Neurogastroenterol Motil 17(suppl 1):50~59
Kumar L / 2017 / Internal anal sphincter : clinical perspective / Surgeon 15:211~226
Cobine CA / 2017 / ANO1 in intramuscular interstitial cells of Cajal plays a key role in the generation of slow waves and tone in the internal anal sphincter / J Physiol 595:2021~2041
Kathleen D Keef / 2019 / Control of Motility in the Internal Anal Sphincter / Journal of Neurogastroenterology and Motility (JNM) 25(2):189~204
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