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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아혈액종양학회 Clinical Pediatric Hematology-Oncology Clinical Pediatric Hematology-Oncology Vol.26 No.2
- 발행연도
- 2019.1
- 수록면
- 110 - 114 (5page)
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초록· 키워드
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Hepatic osteodystrophy is frequent complication in patients with chronic liver disease, particularly with chronic cholestasis. We report a male infant with congenital hepatoblastoma, who had osteodystrophy complicated by multiple bone fractures despite adequate supplementation of fat-soluble vitamins including vitamin D. He was born by Caesarean section because of a 7 cm–sized abdominal mass detected by prenatal ultrasonography. The pathologic diagnosis was hepatoblastoma, PRETEXT staging III or IV. Whole body bone scan at the time of diagnosis showed no abnormal uptake. Oral vitamin D3 of 2,000 IU/day was administered with other fat-soluble vitamins. Serum direct bilirubin level gradually increased up to 28.9 mg/dL at postnatal 6 days and was above 5 mg/dL until 110 days of age. Bony changes consistent with rickets became apparent in left proximal humerus since 48 days of age, and multiple bone fractures developed thereafter. With resolving cholestasis by chemotherapy, his bony lesions improved gradually after add-on treatment of bisphosphonate and parenteral administration of vitamin D with calcium. High level of suspicion and prevention of osteodystrophy is needed in patients with hepatoblastoma, especially when cholestasis persists.
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참고문헌 (14)
참고문헌 신청
Grosfeld J / 2006 / Pediatric surgery / Mosby :502
Ergin H / 2008 / A prenatally detected case of congenital hepatoblastoma / Pathol Oncol Res 14:97~100
Hill SA / 1995 / Bone fractures in children undergoing orthotopic liver transplantation / Pediatr Radiol 25(Suppl 1):S112~S117
Hansen AE / 1940 / Disturbance of osseous and lipid metabolism in a child with primary carcinoma of the liver / J Pediatr 17:9~30
Roberts MH / 1955 / Influence of the liver on bone metabolism; report of two cases / J Am Med Assoc 159:1002~1007
Ergin H / 2008 / A prenatally detected case of congenital hepatoblastoma / Pathol Oncol Res 14:97~100
Hill SA / 1995 / Bone fractures in children undergoing orthotopic liver transplantation / Pediatr Radiol 25(Suppl 1):S112~S117
Hansen AE / 1940 / Disturbance of osseous and lipid metabolism in a child with primary carcinoma of the liver / J Pediatr 17:9~30
Roberts MH / 1955 / Influence of the liver on bone metabolism; report of two cases / J Am Med Assoc 159:1002~1007
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