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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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The emergence of the new disease entity of steroid responsive immunoglobulin G4 (IgG4)-related hepatobiliary disease has generated considerable interest among hepatobiliary society. IgG4-related hepatobiliary disease refers to mainly IgG4- related sclerosing cholangitis (IgG4-SC), and includes a small number of IgG4- related hepatopathy. As IgG4-SC responds well to glucocorticoid therapy, IgG4- SC should be differentiated from cholangiocarcinoma and primary sclerosing cholangitis. Timely diagnosis of IgG4-SC can lead clinicians to prescribe adequate glucocorticoid treatment that can reverse bile duct strictures and cholestatic liver function. Differentiation of IgG4-SC from primary sclerosing cholangitis is sometimes challenging because serum IgG4 and tissue IgG4 have demonstrated low positive predictive value in this setting. Recent research suggested that blood IgG4/IgG RNA ratio by quantitative polymerase chain reaction can be used for differentiation. Although most patients with IgG4-SC/autoimmune pancreatitis respond to glucocorticoid therapy, they frequently experience relapse of disease. The suggested relapse factors included very high serum IgG4, diffuse enlargement of the pancreas, proximal IgG4-SC, and multi-organ involvement. This review discusses the recent advances in the pathogenesis, diagnosis, management, disease relapse, and monitoring disease activity of IgG4-SC.
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참고문헌 (50)
참고문헌 신청
Kamisawa T / 2015 / IgG4-related disease / Lancet 385:1460~1471
Miyabe K / 2018 / Gastrointestinal and extraintestinal manifestations of IgG4-related disease / Gastroenterology 155:990~1003.e1
Kamisawa T / 2003 / A new clinicopathological entity of IgG4-related autoimmune disease / J Gastroenterol 38:982~984
Kamisawa T / 2018 / Advances in IgG4-related pancreatobiliary diseases / Lancet Gastroenterol Hepatol 3:575~585
Inoue D / 2015 / IgG4-related disease: dataset of 235 consecutive patients / Medicine(Baltimore) 94:e680
Miyabe K / 2018 / Gastrointestinal and extraintestinal manifestations of IgG4-related disease / Gastroenterology 155:990~1003.e1
Kamisawa T / 2003 / A new clinicopathological entity of IgG4-related autoimmune disease / J Gastroenterol 38:982~984
Kamisawa T / 2018 / Advances in IgG4-related pancreatobiliary diseases / Lancet Gastroenterol Hepatol 3:575~585
Inoue D / 2015 / IgG4-related disease: dataset of 235 consecutive patients / Medicine(Baltimore) 94:e680
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