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논문 기본 정보

자료유형
학술저널
저자정보
Maryam Khazdouz (Iran University of Medical Sciences) Naser Ebrahimi Daryani (Tehran University of Medical Sciences) Foroogh Alborzi (Tehran University of Medical Sciences) Mir Hadi Jazayeri (Iran University of Medical Sciences) Farnaz Farsi (Iran University of Medical Sciences) Motahareh Hasani (Iran University of Medical Sciences) Javad Heshmati (Kermanshah University of Medical Sciences) Farzad Shidfar (Iran University of Medical Sciences)
저널정보
한국임상영양학회 Clinical Nutrition Research Clinical Nutrition Research Vol.9 No.4
발행연도
2020.1
수록면
284 - 295 (12page)

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초록· 키워드

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Selenium (Se) supplementation may decrease the severity of ulcerative colitis (UC) through the activation of genes responsible for immune modulation. The present research was aimed to assess the effect of Se supplementation on the expression of silent information regulator 1 (SIRT1) and peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) in UC patients. In a double-blind randomized parallel clinical trial, 100 patients with mild-to-moderate active UC met inclusion criteria and divided into 2 groups of treatment (50 patients received selenomethionine [200 μg daily]) and placebo (50 patients received placebo [1 capsule daily]) for 10 weeks. The expression rates of SIRT1 and PGC-1α were examined in the peripheral blood mononuclear cell (PBMC) using the real-time polymerase chain reaction. There was no considerable difference in the mean of baseline demographic and clinical characteristics between groups. Also, there were no significant differences in total energy intake, macronutrients, and micronutrients between groups. The SIRT1 gene expression in the Se group was significantly increased compared to the placebo (p < 0.001). An increase in the expression of the PGC-1α gene in the Se group was not statistically significant. It seems that Se supplementation caused a significant decrease in the inflammatory response of the colon by a significant increase in the expression of the SIRT1 gene.

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