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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 1,281 - 1,290 (10page)
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Background Keratin-associated protein (KAP), the structural protein molecule of hair fibers, plays a key role in determiningthe physical properties of hair. Studies of Krtap11-1 have focused only on its localization. Functional studies of Krtap11-1in hair follicle development have so far not been reported. Objective This study aimed to provide evidence for the role of Krtap11-1 in skin and hair development. Methods Full-length cloning and analysis of Krtap11-1 were conducted to ascertain its function. Overexpression vectors andinterference sequences were constructed and transfected into RAB-9 cells. Quantitative real-time polymerase chain reaction(qRT-PCR) was used to investigate the hair follicle developmental stage of Krtap11-1, the expression of different tissues,and the effects on other hair follicle development-related genes. Results The full length of cloned Krtap11-1 was 947 bp. Krtap11-1 was confirmed to be a hydrophilic protein localizedmostly in mitochondria. The greatest mRNA expression was observed in skin. Using a follicle synchronization model, itwas found that Krtap11-1 mRNA expression levels first increased then decreased over the passage of time, principally duringhair follicle catagen and telogen. Following the overexpression of Krtap11-1, mRNA expression levels of the WNT-2,KRT17, BMP-2, and TGF-β-1 genes increased, and LEF-1 decreased (P < 0.05), the converse after the corresponding useof si-RNA interference. Conclusions Krtap11-1 exerts a promoting effect. The results provide novel insight into the relationship between hair follicledevelopment and Krtap11-1 gene expression.
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참고문헌 (39)
참고문헌 신청
Ahlawat S / 2020 / Skin transcriptome profiling of Changthangi goats highlights the relevance of genes involved in Pashmina production / Sci Rep 10(1):1~10
Andl T / 2002 / WNT signals are required for the initiation of hair follicle development / Dev Cell 2(5):643~653
Bak DH / 2020 / Boehmite enhances hair follicle growth via stimulation of dermal papilla cells by upregulating β-catenin signalling / Exp Dermatol 29(3):341~348
Bazzi H / 2009 / Desmoglein 4 is regulated by transcription factors implicated in hair shaft differentiation / Differentiation 78(5):292~300
Botchkarev VA / 2003 / Molecular biology of hair morphogenesis : development and cycling / J Exp Zool Part B Mol Dev Evol 298(1):164~180
Andl T / 2002 / WNT signals are required for the initiation of hair follicle development / Dev Cell 2(5):643~653
Bak DH / 2020 / Boehmite enhances hair follicle growth via stimulation of dermal papilla cells by upregulating β-catenin signalling / Exp Dermatol 29(3):341~348
Bazzi H / 2009 / Desmoglein 4 is regulated by transcription factors implicated in hair shaft differentiation / Differentiation 78(5):292~300
Botchkarev VA / 2003 / Molecular biology of hair morphogenesis : development and cycling / J Exp Zool Part B Mol Dev Evol 298(1):164~180
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