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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 132 - 137 (6page)
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초록· 키워드
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Objectives: The effect of Salvadora persica sticks on prevention of tooth decay is well established, but the effect of S. persica stick extract (SPE) on the prevention/treatment of osteoporosis has not been studied. The purpose of this study is to provide baseline information of the effectiveness of SPE on ovariectomized (OVX) rat model of osteoporosis. Methods: SPE was administered at 50, 150, and 300 mg/d orally to OVX rats for 16 weeks. Serum osteocalcin, alkaline phosphatase, calcium, and phosphorus, and urinary deoxypyridinoline, calcium, and phosphorus were measured. Bone mineral density (BMD), 3-point bending test, and histomorphometric characteristics of the femoral bone were also examined. Results: SPE at doses of 150 and 300 mg/d, but not 50 mg/d, significantly prevented bone loss in OVX rats as proved by decreased biochemical markers of bone resorption and increased BMD and biomechanical indices of the femoral bone. Conclusions: This study confirms a dose-dependent protective action of SPE on rat OVX model of osteoporosis. This effect needs further investigation at the molecular and clinical levels to provide a natural and cost-effective alternative for the management of postmenopausal osteoporosis.
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등록된 정보가 없습니다.
참고문헌 (33)
참고문헌 신청
Ballane G / 2017 / Worldwide prevalence and incidence of osteoporotic vertebral fractures / Osteoporos Int 28:1531~1542
Johnell O / 2006 / An estimate of the worldwide prevalence and disability associated with osteoporotic fractures / Osteoporos Int 17:1726~1733
Kanis JA / 2012 / A systematic review of hip fracture incidence and probability of fracture worldwide / Osteoporos Int 23:2239~2256
2012 / Abstracts of the IOF regionals, 2nd Middle East & Africa osteoporosis meeting, 6th Pan Arab osteoporosis congress PAOC’6. September 27-october 1, 2012 / Dead Sea, Jordan Osteoporos Int 23(Suppl 6):S655~S700
Dequeker J / 1997 / Hip fracture and osteoporosis in a XIIth Dynasty female skeleton from Lisht, upper Egypt / J Bone Min Res 12:881~888
Johnell O / 2006 / An estimate of the worldwide prevalence and disability associated with osteoporotic fractures / Osteoporos Int 17:1726~1733
Kanis JA / 2012 / A systematic review of hip fracture incidence and probability of fracture worldwide / Osteoporos Int 23:2239~2256
2012 / Abstracts of the IOF regionals, 2nd Middle East & Africa osteoporosis meeting, 6th Pan Arab osteoporosis congress PAOC’6. September 27-october 1, 2012 / Dead Sea, Jordan Osteoporos Int 23(Suppl 6):S655~S700
Dequeker J / 1997 / Hip fracture and osteoporosis in a XIIth Dynasty female skeleton from Lisht, upper Egypt / J Bone Min Res 12:881~888
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