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논문 기본 정보

자료유형
학술저널
저자정보
Kang-su Kang (The Catholic University of Korea) Kun-hyoung Kim (The Catholic University of Korea) Hyun-a Heo (The Catholic University of Korea) Suhyun Park (The Catholic University of Korea) Sung-woon Pyo (The Catholic University of Korea)
저널정보
대한치의학회 Journal of Korean Dental Science Journal of korean dental science Vol.8 No.2
발행연도
2015.12
수록면
65 - 73 (9page)

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Purpose: Parathyroid hormone (PTH) therapy has drawn attention, as an alternative to anti-resorptive drugs since PTH accelerates bone density by anabolic action. The purpose of this study was to identify the effect of intermittent PTH administration on jaw bones of rat undergone bilateral ovariectomy.
Materials and Methods: Nine female Sprague-Dawley rats were divided into three groups. PTH group was ovariectomized (OVX) to induce osteoporosis and PTH 30 μg/kg was administered 1 week after the surgery. In OVX group, ovariectomy was performed and only vehicle was administered by subcutaneous injection 3 times per week. Control group was subjected to sham surgery. The animals were sacrificed 8 weeks after the surgery and specimens were obtained from ilium and upper and lower jaw bones. Histological investigation was carried out by using an optical microscope and micro-computed tomography was taken to examine structural property changes in each bone sample.
Result: In the ilium, the bone volume ratio (bone volume/total volume, BV/TV) of PTH, OVX and control groups was 53.75%±7.57%, 50.61%±12.89%, 76.20%±5.92% (P=0.061) and bone mineral density (BMD) was 1.12±0.09, 0.88±0.48, 1.38±0.07 g/cm³ (P=0.061). In the mandible, BV/TV of PTH, OVX and control groups was 64.60%±12.17%, 58.26%±9.63%, 67.54%±14.74% (P=0.670) and BMD was 1.21±0.17, 1.19±0.13, 1.27±0.18 g/cm³ (P=0.587). In the maxilla, BV/TV of PTH, OVX and control groups was 61.19%±8.92%, 52.50%±11.22%, 64.60%±12.17% (P=0.430) and BMD was 1.20±0.11, 1.11±0.16, 1.21±0.17 g/cm³ (P=0.561). No statistically significant difference was found in any variables in all groups. Histological observation revealed that the ilium in OVX group demonstrated sparsely formed trabecular bones compared with other groups. However, upper and lower trabecular bones did not present significant differences.
Conclusion: Intermittent administration of PTH appears to affect the microstructure of rat jaw bones, but statistical significance was not found. However, the measurements in this study partly implicated the possible anabolic effect of PTH in vivo.

목차

Introduction
Materials and Methods
Result
Discussion
Conclusion
References

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UCI(KEPA) : I410-ECN-0101-2016-515-002234296