지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.12
- 수록면
- 65 - 73 (9page)
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초록· 키워드
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Purpose: Parathyroid hormone (PTH) therapy has drawn attention, as an alternative to anti-resorptive drugs since PTH accelerates bone density by anabolic action. The purpose of this study was to identify the effect of intermittent PTH administration on jaw bones of rat undergone bilateral ovariectomy.
Materials and Methods: Nine female Sprague-Dawley rats were divided into three groups. PTH group was ovariectomized (OVX) to induce osteoporosis and PTH 30 μg/kg was administered 1 week after the surgery. In OVX group, ovariectomy was performed and only vehicle was administered by subcutaneous injection 3 times per week. Control group was subjected to sham surgery. The animals were sacrificed 8 weeks after the surgery and specimens were obtained from ilium and upper and lower jaw bones. Histological investigation was carried out by using an optical microscope and micro-computed tomography was taken to examine structural property changes in each bone sample.
Result: In the ilium, the bone volume ratio (bone volume/total volume, BV/TV) of PTH, OVX and control groups was 53.75%±7.57%, 50.61%±12.89%, 76.20%±5.92% (P=0.061) and bone mineral density (BMD) was 1.12±0.09, 0.88±0.48, 1.38±0.07 g/cm³ (P=0.061). In the mandible, BV/TV of PTH, OVX and control groups was 64.60%±12.17%, 58.26%±9.63%, 67.54%±14.74% (P=0.670) and BMD was 1.21±0.17, 1.19±0.13, 1.27±0.18 g/cm³ (P=0.587). In the maxilla, BV/TV of PTH, OVX and control groups was 61.19%±8.92%, 52.50%±11.22%, 64.60%±12.17% (P=0.430) and BMD was 1.20±0.11, 1.11±0.16, 1.21±0.17 g/cm³ (P=0.561). No statistically significant difference was found in any variables in all groups. Histological observation revealed that the ilium in OVX group demonstrated sparsely formed trabecular bones compared with other groups. However, upper and lower trabecular bones did not present significant differences.
Conclusion: Intermittent administration of PTH appears to affect the microstructure of rat jaw bones, but statistical significance was not found. However, the measurements in this study partly implicated the possible anabolic effect of PTH in vivo.
Materials and Methods: Nine female Sprague-Dawley rats were divided into three groups. PTH group was ovariectomized (OVX) to induce osteoporosis and PTH 30 μg/kg was administered 1 week after the surgery. In OVX group, ovariectomy was performed and only vehicle was administered by subcutaneous injection 3 times per week. Control group was subjected to sham surgery. The animals were sacrificed 8 weeks after the surgery and specimens were obtained from ilium and upper and lower jaw bones. Histological investigation was carried out by using an optical microscope and micro-computed tomography was taken to examine structural property changes in each bone sample.
Result: In the ilium, the bone volume ratio (bone volume/total volume, BV/TV) of PTH, OVX and control groups was 53.75%±7.57%, 50.61%±12.89%, 76.20%±5.92% (P=0.061) and bone mineral density (BMD) was 1.12±0.09, 0.88±0.48, 1.38±0.07 g/cm³ (P=0.061). In the mandible, BV/TV of PTH, OVX and control groups was 64.60%±12.17%, 58.26%±9.63%, 67.54%±14.74% (P=0.670) and BMD was 1.21±0.17, 1.19±0.13, 1.27±0.18 g/cm³ (P=0.587). In the maxilla, BV/TV of PTH, OVX and control groups was 61.19%±8.92%, 52.50%±11.22%, 64.60%±12.17% (P=0.430) and BMD was 1.20±0.11, 1.11±0.16, 1.21±0.17 g/cm³ (P=0.561). No statistically significant difference was found in any variables in all groups. Histological observation revealed that the ilium in OVX group demonstrated sparsely formed trabecular bones compared with other groups. However, upper and lower trabecular bones did not present significant differences.
Conclusion: Intermittent administration of PTH appears to affect the microstructure of rat jaw bones, but statistical significance was not found. However, the measurements in this study partly implicated the possible anabolic effect of PTH in vivo.
목차
Introduction
Materials and Methods
Result
Discussion
Conclusion
References
참고문헌 (30)
참고문헌 신청
[학술지(정기간행물)] - Kasugai S / 2006 / Dental implant treatment to osteoporosis patients / Clin Calcium 16 : 348 ~ 353
[학술지(정기간행물)] - Ejiri S / 2008 / Estrogen deficiency and its effect on the jaw bones / J Bone Miner Metab 26 : 409 ~ 415
[학술지(정기간행물)] - Teitelbaum AP / 1982 / Functional properties of parathyroid hormone receptors in kidney and bone / Adv Exp Med Biol 151 : 535 ~ 548
[학술지(정기간행물)] - Wronski TJ / 1985 / Skeletal alterations in ovariectomized rats / Calcif Tissue Int 37 : 324 ~ 328
[학술지(정기간행물)] - Aggarwal P / 2012 / Parathyroid hormone and its effects on dental tissues / Oral Dis 18 : 48 ~ 54
[학술지(정기간행물)] - Ejiri S / 2008 / Estrogen deficiency and its effect on the jaw bones / J Bone Miner Metab 26 : 409 ~ 415
[학술지(정기간행물)] - Teitelbaum AP / 1982 / Functional properties of parathyroid hormone receptors in kidney and bone / Adv Exp Med Biol 151 : 535 ~ 548
[학술지(정기간행물)] - Wronski TJ / 1985 / Skeletal alterations in ovariectomized rats / Calcif Tissue Int 37 : 324 ~ 328
[학술지(정기간행물)] - Aggarwal P / 2012 / Parathyroid hormone and its effects on dental tissues / Oral Dis 18 : 48 ~ 54
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UCI(KEPA) : I410-ECN-0101-2016-515-002234296