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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 164 - 169 (6page)
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Objective: To map the progression of osteoporosis following spinal cord injury in mice in specific areas and analyze changes in parathyroid hormone (PTH) and ion levels which could be responsible for overall bone loss. Summary of background data: Spinal cord injury rapidly induces severe bone loss compared to other conditions, yet the cause of this bone loss has not been identified. Studies suggest the bone loss after injury is not solely due to disuse. Methods: To quantify bone loss we weighed individual bones and measured bone mineral density using dual energy X-ray absorptiometry at acute (1 week) and chronic (4 week) time points following a T9 contusion. An ELISA was used to measure blood PTH levels at 1 and 4 weeks after injury. Calcium and phosphate levels were also analyzed at 4 weeks following injury at the University of Miami pathology core. Results: We observed a significant decrease in bone mineral density in hind limbs after an acute injury, and found this bone loss to progress over time. Furthermore, following chronic injury a decrease in bone mineral density is also observed in bones above the level of injury and in the total bone mineral density. We observed a significant decrease in parathyroid hormone levels in injured mice at the chronic time point, but not at the acute time point which suggests this could be involved in the global bone loss following injury. We also observed a significant increase in serum calcium levels following injury which could account for the imbalance of PTH levels.
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등록된 정보가 없습니다.
참고문헌 (35)
참고문헌 신청
Battaglino RA / 2012 / Spinal cord injuryinduced osteoporosis: pathogenesis and emerging therapies / Curr Osteoporos Rep 10:278~285
Dionyssiotis Y / 2011 / Spinal cord injury-related bone impairment and fractures:an update on epidemiology and physiopathological mechanisms / J Musculoskelet Neuronal Interact 11:257~265
Giangregorio L / 2006 / Bone loss and muscle atrophy in spinal cord injury: epidemiology, fracture prediction, and rehabilitation strategies / J Spinal Cord Med 29:489~500
Jiang SD / 2006 / Osteoporosis after spinal cord injury / Osteoporos Int 17:180~192
Jiang SD / 2006 / Mechanisms of osteoporosis in spinal cord injury / Clin Endocrinol (Oxf) 65:555~565
Dionyssiotis Y / 2011 / Spinal cord injury-related bone impairment and fractures:an update on epidemiology and physiopathological mechanisms / J Musculoskelet Neuronal Interact 11:257~265
Giangregorio L / 2006 / Bone loss and muscle atrophy in spinal cord injury: epidemiology, fracture prediction, and rehabilitation strategies / J Spinal Cord Med 29:489~500
Jiang SD / 2006 / Osteoporosis after spinal cord injury / Osteoporos Int 17:180~192
Jiang SD / 2006 / Mechanisms of osteoporosis in spinal cord injury / Clin Endocrinol (Oxf) 65:555~565
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