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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아내분비학회 Annals of Pediatirc Endocrinology & Metabolism Annals of Pediatirc Endocrinology & Metabolism 제25권 제1호
- 발행연도
- 2020.1
- 수록면
- 1 - 9 (9page)
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초록· 키워드
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Acute lymphoblastic leukemia (ALL), currently the most common pediatric leukemia, has a high curability rate of up to 90%. Endocrine disorders are highly prevalent in children with ALL, and skeletal morbidity is a major issue induced by multiple factors associated with ALL. Leukemia itself is a predominant risk factor for decreased bone formation, and major bone destruction occurs secondary to chemotherapeutic agents. Glucocorticoids are cornerstone drugs used throughout the course of ALL treatment that exert significant effects on demineralization and osteoclastogenesis. After completion of treatment, ALL survivors are prone to multiple hormone deficiencies that eventually affect bone mineral accrual. Dual-energy X-ray absorptiometry, the most widely used method of measuring bone mineral density, is used to determine the presence of childhood osteoporosis and vertebral fracture. Supplementation with calcium and vitamin D, administration of pyrophosphate analogues, and promotion of mobility and exercise are effective options to prevent further bone resorption and fracture incidence. This review focuses on addressing bone morbidity after pediatric ALL treatment and provides an overview of bone pathology based on skeletal outcomes to increase awareness among pediatric hemato-oncologists and endocrinologists.
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참고문헌 (73)
참고문헌 신청
이재욱 / 2017 / Prognostic factors and treatment of pediatric acute lymphoblastic leukemia / Clinical and Experimental Pediatrics 60(5):129~137
Inaba H / 2013 / Acute lymphoblastic leukaemia / Lancet 381:1943~1955
Demidowicz E / 2019 / Outcome of pediatric acute lymphoblastic leukemia : sixty years of progress / Anticancer Res 39:5203~5207
Sklar CA / 2018 / Hypothalamic-pituitary and growth disorders in survivors of childhood cancer : an Endocrine Society Clinical Practice Guideline / J Clin Endocrinol Metab 103:2761~2784
Howard SC / 2002 / Endocrine complications in pediatric patients with acute lymphoblastic leukemia / Blood Rev 16:225~243
Inaba H / 2013 / Acute lymphoblastic leukaemia / Lancet 381:1943~1955
Demidowicz E / 2019 / Outcome of pediatric acute lymphoblastic leukemia : sixty years of progress / Anticancer Res 39:5203~5207
Sklar CA / 2018 / Hypothalamic-pituitary and growth disorders in survivors of childhood cancer : an Endocrine Society Clinical Practice Guideline / J Clin Endocrinol Metab 103:2761~2784
Howard SC / 2002 / Endocrine complications in pediatric patients with acute lymphoblastic leukemia / Blood Rev 16:225~243
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