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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 535 - 541 (7page)
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초록· 키워드
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Angiotensin II (Ang II) induces the pathological process of vascular structures, including renal glomeruli by hemodynamic and nonhemodynamic direct effects. In kidneys, Ang II plays an important role in the development of proteinuria by the modification of podocyte molecules. We have previously found that Ang II suppressed podocyte AMP-activated protein kinase (AMPK) via Ang II type 1 receptor and MAPK signaling pathway. In the present study, we investigated the roles of AMPK on the changes of p130Cas of podocyte by Ang II. We cultured mouse podocytes and treated them with various concentrations of Ang II and AMPK-modulating agents and analyzed the changes of p130Cas by confocal imaging and western blotting. In immunofluorescence study, Ang II decreased the intensity of p130Cas and changed its localization from peripheral cytoplasm into perinuclear areas in a concentrated pattern in podocytes. Ang II also reduced the amount of p130Cas in time and dose-sensitive manners. AMPK activators, metformin and AICAR, restored the suppressed and mal-localized p130Cas significantly, whereas, compound C, an AMPK inhibitor, further aggravated the changes of p130Cas. Losartan, an Ang II type 1 receptor antagonist, recovered the abnormal changes of p130Cas suppressed by Ang II. These results suggest that Ang II induces the relocalization and suppression of podocyte p130Cas by the suppression of AMPK via Ang II type 1 receptor, which would contribute to Ang II-induced podocyte injury.
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등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Remuzzi G / 2006 / Mechanisms of progression and regression of renal lesions of chronic nephropathies and diabetes / J Clin Invest 116:288~296
Kobori H / 2007 / The intrarenal renin-angiotensin system : from physiology to the pathobiology of hypertension and kidney disease / Pharmacol Rev 59:251~287
Wolf G / 2000 / Angiotensin II as a mediator of tubulointerstitial injury / Nephrol Dial Transplant 6:61~63
Luft FC / 2002 / Proinflammatory effects of angiotensin II and endothelin : targets for progression of cardiovascular and renal diseases / Curr Opin Nephrol Hypertens 11:59~66
Benigni A / 2001 / Blocking angiotensin II synthesis/activity preserves glomerular nephrin in rats with severe nephrosis / J Am Soc Nephrol 12:941~948
Kobori H / 2007 / The intrarenal renin-angiotensin system : from physiology to the pathobiology of hypertension and kidney disease / Pharmacol Rev 59:251~287
Wolf G / 2000 / Angiotensin II as a mediator of tubulointerstitial injury / Nephrol Dial Transplant 6:61~63
Luft FC / 2002 / Proinflammatory effects of angiotensin II and endothelin : targets for progression of cardiovascular and renal diseases / Curr Opin Nephrol Hypertens 11:59~66
Benigni A / 2001 / Blocking angiotensin II synthesis/activity preserves glomerular nephrin in rats with severe nephrosis / J Am Soc Nephrol 12:941~948
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