지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 22 - 27 (6page)
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Purpose: Podocytes are important architectures that maintain the crucial roles of glomerular filtration barrier functions. Despite this structural importance, however, the mechanisms of the changes in podocytes that can be an important pathogenesis of minimal change nephrotic syndrome (MCNS) are not clear yet. The aim of this study was to investigate whether apoptosis is induced by interleukin (IL)-13 in cultured human podocytes. Methods: Human podocytes were treated with different IL-13 doses and apoptotic cells were analyzed using terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL assay) and fluorescence-activated cell sorting (FACS). Results: The IL-13 increased the number of TUNEL-positive cells in a dose-dependent manner at 6 and 18 hours (P <0.05 and P <0.05, respectively). The apoptosis rate was appeared to be increased slightly in the IL-13-stimulated podocytes (8.63 %, 13.02%, and 14.46%; 3, 10 and 30 ng/mL, respectively) than in the control cells (7.66%) at 12 hours by FACS assay. Conclusion: Our study revealed that IL-13 expression may increase podocyte apoptosis. Blocking the IL-13 signal pathway can potentially play an important role in regulating the apoptosis of podocytes.
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등록된 정보가 없습니다.
참고문헌 (31)
참고문헌 신청
Churg J / 1970 / Pathology of the nephrotic syndrome in children: a report for the International Study of Kidney Disease in Children / Lancet 760:1299~1230
Haas M / 1997 / Changing etiologies of unexplained adult nephrotic syndrome: a comparison of renal biopsy findings from 1976-1979 and 1995-1997 / Am J Kidney Dis 30:621
Trompeter RS / 1985 / Longterm outcome for children with minimal-change nephrotic syndrome / Lancet 1:368~370
1981 / A report of the International Study of Kidney Disease in Children. The primary nephrotic syndrome in children. Identification of patients with minimal change nephrotic syndrome from initial response to prednisone / J Pediatr 98:561~564
Teeninga N / 2013 / Extending prednisolone treatment does not reduce relapses in childhood nephrotic syndrome / J Am Soc Nephrol 24:149~159
Haas M / 1997 / Changing etiologies of unexplained adult nephrotic syndrome: a comparison of renal biopsy findings from 1976-1979 and 1995-1997 / Am J Kidney Dis 30:621
Trompeter RS / 1985 / Longterm outcome for children with minimal-change nephrotic syndrome / Lancet 1:368~370
1981 / A report of the International Study of Kidney Disease in Children. The primary nephrotic syndrome in children. Identification of patients with minimal change nephrotic syndrome from initial response to prednisone / J Pediatr 98:561~564
Teeninga N / 2013 / Extending prednisolone treatment does not reduce relapses in childhood nephrotic syndrome / J Am Soc Nephrol 24:149~159
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