지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.9
- 수록면
- 134 - 142 (9page)
- DOI
- 10.1186/s40824-015-0040-4
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초록· 키워드
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Background: Angiogenin (ANG) is a potent stimulator of angiogenesis. The aim of this study was to fabricate an ANG-loaded scaffold and to evaluate its angiogenic and osteogenic effects. In this study, we fabricated an ANG-loaded scaffold using bovine bone powder and fibrin glue. We then evaluated the structural, morphological, and mechanical properties of the scaffold and the in vitro release profile of ANG. Cell proliferation, viability, and adhesion were evaluated using endothelial cells in vitro, and angiogenesis and new bone formation were evaluated using a rabbit calvarial defect model in vivo. Results: Micro-computed tomography imaging showed that the bone powder was uniformly distributed in the scaffold, and scanning electron microscopy showed that the bone powder was bridged by polymerized fibrin. The porosity and compressive strength of the scaffolds were ~60 % and ~0.9 MPa, respectively, and were not significantly altered by ANG loading. In vitro, at 7 days, approximately 0.4 μg and 1.3 μg of the ANG were released from the FB/ANG 0.5 and FB/ANG 2.0, respectively and sustained slow release was observed until 25 days. The released ANG stimulated cell proliferation and adherence and was not cytotoxic. Furthermore, in vivo implantation resulted in enhanced angiogenesis, and new bone formation depended on the amount of loaded ANG. Conclusions: These studies demonstrate that a fibrin and bone powder scaffold loaded with ANG might be useful to promote bone regeneration by enhanced angiogenesis.
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참고문헌 (33)
참고문헌 신청
Kuboki Y. / 2001 / Geometry of carriers controlling phenotypic expression in BMP-induced osteogenesis and chondrogenesis / J Bone Joint Surg Am 83-A(Suppl 1):S105~S115
Murata M. / 2012 / Acid-insoluble human dentin as carrier material for recombinant human BMP-2 / J Biomed Mater Res A 100:571~577
Hankenson KD. / 2011 / Angiogenesis in bone regeneration / Injury 42:556~561
Ozturk BY. / 2013 / The treatment of segmental bone defects in rabbit tibiae with vascular endothelial growth factor(VEGF)-loaded gelatin/hydroxyapatite"cryogel"scaffold / J Pediatr Orthop B 23:767~774
Devescovi V. / 2008 / Growth factors in bone repair / Chir Organi Mov 92:161~168
Murata M. / 2012 / Acid-insoluble human dentin as carrier material for recombinant human BMP-2 / J Biomed Mater Res A 100:571~577
Hankenson KD. / 2011 / Angiogenesis in bone regeneration / Injury 42:556~561
Ozturk BY. / 2013 / The treatment of segmental bone defects in rabbit tibiae with vascular endothelial growth factor(VEGF)-loaded gelatin/hydroxyapatite"cryogel"scaffold / J Pediatr Orthop B 23:767~774
Devescovi V. / 2008 / Growth factors in bone repair / Chir Organi Mov 92:161~168
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