지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 54 - 59 (6page)
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초록· 키워드
오류제보하기
Hemodialysis (HD) patients experience vascular calcification, ultimately leading to high mortality rates. Previously, we reported associations between soluble receptor for advanced glycation end products (sRAGEs) and extracellular newly identified RAGE-binding protein S100A12 (EN-RAGE) and vascular calcification. Here, we extended our observations, investigating whether these biomarkers may be useful for predicting cardiovascular morbidity and mortality in these subjects. Thus, we evaluated the relationship between sRAGE and S100A12 and mortality in long-term HD patients. This was a prospective observational cohort study in 199 HD patients from an extended analysis of our previous study. Plasma sRAGE, S100A12, comorbidities, and other traditional risk factors were investigated. The cumulative incidences for death using Cox proportional hazards regression were evaluated in multivariable analyses. The observation period was 44 months. During the observation period, 27 (13.6%) patients died. Univariate analysis demonstrated that S100A12 was correlated with diabetes (P = 0.040) and high-sensitivity C-reactive protein (hsCRP) (P = 0.006). In multivariable analyses, plasma sRAGE (hazard ratio [HR] = 1.155; 95% confidence interval [CI] = 0.612–2.183; P = 0.656) and S100A12 (HR = 0.960; 95% CI = 0.566–1.630; P = 0.881) were not associated with mortality in HD patients, although traditional predictors of mortality, including age, history of cardiovascular diseases (CVDs), and serum levels of albumin and hsCRP were related to mortality. Powerful predictors of mortality were age, CVD, and albumin levels. Plasma sRAGE and S100A12 may be weak surrogate markers for predicting all-cause mortality in patients undergoing HD, although S100A12 was partly related to diabetes and inflammation.
목차
등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Wanner C / 2016 / The heart and vascular system in dialysis / Lancet 388:276~284
Klarenbach SW / 2014 / Economic evaluation of dialysis therapies / Nat Rev Nephrol 10:644~652
Stack AG / 2001 / Prevalence and clinical correlates of coronary artery disease among new dialysis patients in the United States : a cross-sectional study / J Am Soc Nephrol 12:1516~1523
Stompór T / 2007 / An overview of the pathophysiology of vascular calcification in chronic kidney disease / Perit Dial Int 27(Suppl 2):S215~S222
London GM / 2003 / Arterial media calcification in end-stage renal disease : impact on all-cause and cardiovascular mortality / Nephrol Dial Transplant 18:1731~1740
Klarenbach SW / 2014 / Economic evaluation of dialysis therapies / Nat Rev Nephrol 10:644~652
Stack AG / 2001 / Prevalence and clinical correlates of coronary artery disease among new dialysis patients in the United States : a cross-sectional study / J Am Soc Nephrol 12:1516~1523
Stompór T / 2007 / An overview of the pathophysiology of vascular calcification in chronic kidney disease / Perit Dial Int 27(Suppl 2):S215~S222
London GM / 2003 / Arterial media calcification in end-stage renal disease : impact on all-cause and cardiovascular mortality / Nephrol Dial Transplant 18:1731~1740
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