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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 70 - 76 (7page)
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초록· 키워드
오류제보하기
Bone mineral density (BMD) has been suggested to be associated with atherosclerosis. In the present study, we evaluated the association between lumbar BMD and the segments of carotid intima-media thickness (CIMT), a surrogate marker of subclinical atherosclerosis, in Korean adults, with consideration of sex and menopause status. Among 1,679 Korean adults who enrolled in a Healthy Twin Study, 723 men, 690 premenopausal women, and 266 postmenopausal women measured the CIMT at the common carotid artery intima-media thickness (CCA-IMT), carotid bifurcation intima-media thickness (BIF-IMT), internal carotid artery intima-media thickness (ICA-IMT) using B-mode ultrasound and lumbar BMD using dual-energy X-ray absorptiometry. The composite CIMT was calculated as the mean value of three CIMTs. The association was evaluated using linear mixed models. In premenopausal women, lumbar BMD was positively associated with composite CIMT and with CCA-IMT (P = 0.008 and 0.002, respectively). However, no association was observed between BMD and CIMT in men or in postmenopausal women. Stratified analysis revealed the effect of body mass index (BMI) on the association between BMD and CIME. The positive association in premenopausal women persisted only in low BMI (< 25 kg/m2) group, whereas a positive association appeared at high BMI (≥ 25 kg/m2) group in men. A high lumbar BMD may indicate an elevated risk of subclinical atherosclerosis in premenopausal women and men with high BMI.
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참고문헌 (35)
참고문헌 신청
Sarkisian CA / 2000 / Modifiable risk factors predict functional decline among older women: a prospectively validated clinical prediction tool. The study of osteoporotic fractures research group / J Am Geriatr Soc 48:170~178
Bliuc D / 2015 / Accelerated bone loss and increased post-fracture mortality in elderly women and men / Osteoporos Int 26:1331~1339
Tabas I / 2015 / Recent insights into the cellular biology of atherosclerosis / J Cell Biol 209:13~22
Hofbauer LC / 2007 / Vascular calcification and osteoporosis--from clinical observation towards molecular understanding / Osteoporos Int 18:251~259
Demer LL / 2002 / Vascular calcification and osteoporosis : inflammatory responses to oxidized lipids / Int J Epidemiol 31:737~741
Bliuc D / 2015 / Accelerated bone loss and increased post-fracture mortality in elderly women and men / Osteoporos Int 26:1331~1339
Tabas I / 2015 / Recent insights into the cellular biology of atherosclerosis / J Cell Biol 209:13~22
Hofbauer LC / 2007 / Vascular calcification and osteoporosis--from clinical observation towards molecular understanding / Osteoporos Int 18:251~259
Demer LL / 2002 / Vascular calcification and osteoporosis : inflammatory responses to oxidized lipids / Int J Epidemiol 31:737~741
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