지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 42 - 51 (10page)
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초록· 키워드
오류제보하기
Background: We evaluated the clinical performance of [-2]proPSA (p2PSA) and its derivatives in predicting the presence and aggressiveness of prostate cancer (PCa) in Korean men. Methods: A total of 246 men with total prostate-specific antigen (tPSA) ≥ 3.5 ng/mL who underwent their first prostate biopsy were included in this prospective, multicenter, observational study. Diagnostic accuracy of tPSA, free-to-total PSA ratio (%fPSA), p2PSA, %p2PSA, and the Beckman Coulter prostate health index (PHI) was assessed by receiver operating characteristic curve analyses and logistic regression analyses. Results: Overall, PCa was detected in 125 (50.8%) subjects. In men with tPSA 3.5–10 ng/mL, the detection rate of PCa was 39.4% (61/155). In this group, PHI and %p2PSA were the most accurate predictors of PCa and significantly outperformed tPSA and %fPSA; area under the curve for tPSA, %fPSA, %p2PSA, and PHI was 0.56, 0.69, 0.74, and 0.76, respectively. PHI was also the strongest predictor of PCa with Gleason score ≥ 7. Conclusion: This study demonstrates the superior clinical performance of %p2PSA and PHI in predicting the presence and aggressiveness of PCa in Korean men. The %p2PSA and PHI appear to improve detection of PCa and provide prognostic information.
목차
등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
Hatakeyama S / 2017 / Recent progress and perspectives on prostate cancer biomarkers / Int J Clin Oncol 22(2):214~221
Saini S / 2016 / PSA and beyond: alternative prostate cancer biomarkers / Cell Oncol (Dordr) 39(2):97~106
Schroder FH / 2009 / Screening and prostate-cancer mortality in a randomized European study / N Engl J Med 360(13):1320~1328
Andriole GL / 2012 / Prostate cancer screening in the randomized Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial: mortality results after 13 years of follow-up / J Natl Cancer Inst 104(2):125~132
Catalona WJ / 1998 / Use of the percentage of free prostate-specific antigen to enhance differentiation of prostate cancer from benign prostatic disease: a prospective multicenter clinical trial / JAMA 279(19):1542~1547
Saini S / 2016 / PSA and beyond: alternative prostate cancer biomarkers / Cell Oncol (Dordr) 39(2):97~106
Schroder FH / 2009 / Screening and prostate-cancer mortality in a randomized European study / N Engl J Med 360(13):1320~1328
Andriole GL / 2012 / Prostate cancer screening in the randomized Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial: mortality results after 13 years of follow-up / J Natl Cancer Inst 104(2):125~132
Catalona WJ / 1998 / Use of the percentage of free prostate-specific antigen to enhance differentiation of prostate cancer from benign prostatic disease: a prospective multicenter clinical trial / JAMA 279(19):1542~1547
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