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자료유형
학술저널
저자정보
백경완 (부산대학교) 차희재 (고신대학교) 옥미선 (고신대학교) 김홍수 (순천향대학교) 김정안 (부산대학교 스포츠의학부) 박정준 (부산대학교)
저널정보
한국운동재활학회 Journal of exercise rehabilitation Journal of exercise rehabilitation Vol.14 No.1
발행연도
2018.1
수록면
32 - 38 (7page)

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Previously, we monitored the expression level of the pro-apoptotic proteins caspase-3 and separated poly-ADP-ribose polymerase in the skeletal muscle of high-fat diet-induced obese rats in order to assess muscle damage. In this study, we analyzed whether exercise or dietary adjustment was more effective at preventing high-fat diet-induced muscle damage. High-fat diet-induced obese rats were divided into three groups: the high-fat diet (HFD), the combined high-fat diet and exercise (HFD+EXE), and the dietary adjustment (DA) groups. For 6 weeks, the HFD+EXE group was subjected to exercise on an animal treadmill. Capsase-3 protein was quantified, and histopathology of the soleus muscle was performed. Both the HFD+EXE and DA interventions resulted in a reduction of lipid accumulation in the soleus muscle, and nucleus infiltration was significantly lower in the DA group. The inflammatory response, caspase-3 level, and relative muscle weight were significantly higher in the HFD+EXE group compared to the HFD group. An increase in intramyocellular lipids in the soleus muscle by obesity and exercise stimulated apoptosis. When the rats exercised, muscle growth was normal and unrelated to the effects of lipid accumulation. These data indicate that exercise was more effective than dietary adjustment in reducing lipid accumulation and increasing muscle metabolism.

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