지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 693 - 705 (13page)
이용수
초록· 키워드
오류제보하기
Cells regulate functionally related genes cisand trans-contacts in order to perform specific biological roles. To understand the cryptic spatial genomic contexts underlying these biological functions, we analyzed the gene association data from the gene ontology (GO) database and the genomic spatial organization data obtained by analysis of chromosome conformation capture (3C)-based data from the Sequence Read Archive, where GO and 3Cbased data were used to measure functional similarity and spatial proximity, respectively, between genomic loci. In the human genome and the fission yeast genome, we observed that correlation between the two measures was statistically significant on a genome-wide scale. Specifically, it is also confirmed that the genomic spatial architecture is affected by functional similarity of genes by showing better correlation of functional similarities with spatial distances estimated by contact frequencies than those estimated by genomic distances for cis-contacts. Furthermore, we analyzed distances between the genomic segments sharing the same GO term using the two-sample t test, found that the genomic segments identified by various GO terms are spatially located closer than the average distance over statistically-valid contacts, and provided a list of the GO terms. The results suggested that genomic loci with similar biological functions are situated in close proximity to each other in the nuclear space by aggregating functionally related genes in a short spatial range.
목차
등록된 정보가 없습니다.
참고문헌 (52)
참고문헌 신청
Ashburner M / 2000 / Gene ontology: tool for the unification of biology. The Gene Ontology Consortium / Nat Genet 25:25~29
Beissbarth T / 2004 / GOstat: find statistically overrepresented gene ontologies within a group of genes / Bioinformatics 20:1464~1465
Chagoyen M / 2006 / A literature-based similarity metric for biological processes / BMC Bioinform 7:363
Chang CW / 2011 / Identification of human housekeeping genes and tissue-selective genes by microarray meta-analysis / PLoS ONE 6:e22859
Cremer T / 2001 / Chromosome territories, nuclear architecture and gene regulation in mammalian cells / Nat Rev Genet 2:292~301
Beissbarth T / 2004 / GOstat: find statistically overrepresented gene ontologies within a group of genes / Bioinformatics 20:1464~1465
Chagoyen M / 2006 / A literature-based similarity metric for biological processes / BMC Bioinform 7:363
Chang CW / 2011 / Identification of human housekeeping genes and tissue-selective genes by microarray meta-analysis / PLoS ONE 6:e22859
Cremer T / 2001 / Chromosome territories, nuclear architecture and gene regulation in mammalian cells / Nat Rev Genet 2:292~301
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Unlocking biological mechanisms with integrative functional genomics approaches
Molecules and Cells
2024 .01
-
Deep Learning Identification of the Gene-Gene Interactions without the Need of thorough Investigation of Each Genomic Combination
Journal of The Korean Data Analysis Society
2017 .01
-
An Ontology-Based GIS for Genomic Data Management of Rumen Microbes
Genomics & informatics
2015 .01
-
Pan-Genomics of Lactobacillus plantarum Revealed Group-Specific Genomic Profiles without Habitat Association
Journal of Microbiology and Biotechnology
2018 .01
-
Comparative Genomics Reveals the Core and Accessory Genomes of Streptomyces Species
Journal of Microbiology and Biotechnology
2015 .01
-
Genomic and Metabolic Features of Enterococcus faecium Revealed by Pan-genomic and Metatranscriptomic Analysis
한국미생물학회 학술대회논문집
2020 .10
-
Research on the Genomic Functionality Using Industrial Animal-derived Microbial Genome Analysis and Bioinformatics
한국미생물학회 학술대회논문집
2022 .10
-
The genomes and transposable elements in plants: are they friends or foes?
Genes & Genomics
2017 .01
-
A Genome-wide Screening of Target Genes against Doxorubicin in Fission Yeast
한국미생물학회 학술대회논문집
2022 .10
-
Genomic Insights into the Rice Blast Fungus through Estimation of Gene Emergence Time in Phylogenetic Context
Mycobiology
2018 .01
-
Fungal Genomics in Dermatology
대한의진균학회지
2019 .01
-
Identifying Vulnerabilities in Fungal Pathogens through Functional and Chemical Genomic Analyses
한국미생물학회 학술대회논문집
2021 .08
-
Genomic Analysis of Microorganisms Isolated from Kimchi and Human
한국미생물학회 학술대회논문집
2019 .04
-
Validation of a Fission Yeast Gene Deletion Library by Whole Genome Sequencing
한국미생물학회 학술대회논문집
2022 .10
-
A Functional Genomic Approach to Pseudomonas fluorescence DR397 Reveals the Gene Networks Evolving Plant Drought Resistance
한국미생물학회 학술대회논문집
2020 .10
-
Functional Genomics Approaches to Understand Dandruff-associated Malassezia Yeast
한국미생물학회 학술대회논문집
2017 .04
-
Isolation and Genomic Study of Marine SAR202 Bacteria
한국미생물학회 학술대회논문집
2021 .08
-
Genome-wide association analysis reveals the genetic locus for high reproduction trait in Chinese Arbas Cashmere goat
Genes & Genomics
2020 .01
-
Genomic perspectives on epigenetics
Genes & Genomics
2022 .03
-
Comparative Genomic Analysis of Fusobacterium Species Using Multiple Metagenome-assembled Genomes
한국미생물학회 학술대회논문집
2021 .08
이 논문의 저자 정보
최근 본 자료
댓글(0)
0