지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 353 - 359 (7page)
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초록· 키워드
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Background: Cushing syndrome is characterized by glucose intolerance, cardiovascular disease, and an enhanced systemic inflammatory response caused by chronic exposure to excess cortisol. Eosinopenia is frequently observed in patients with adrenal Cushing syndrome, but the relationship between the eosinophil count in peripheral blood and indicators of glucose level in patients with adrenal Cushing syndrome has not been determined. Methods: A retrospective study was undertaken of the clinical and laboratory findings of 40 patients diagnosed with adrenal Cushing syndrome at Chungnam National University Hospital from January 2006 to December 2016. Clinical characteristics, complete blood cell counts with white blood cell differential, measures of their endocrine function, description of imaging studies, and pathologic findings were obtained from their medical records. Results: Eosinophil composition and count were restored by surgical treatment of all of the patients with adrenal Cushing disease. The eosinophil count was inversely correlated with serum and urine cortisol, glycated hemoglobin, and inflammatory markers in the patients with adrenal Cushing syndrome. Conclusion: Smaller eosinophil populations in patients with adrenal Cushing syndrome tend to be correlated with higher levels of blood sugar and glycated hemoglobin. This study suggests that peripheral blood eosinophil composition or count may be associated with serum glucose levels in patients with adrenal Cushing syndrome.
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등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Chanson P / 2010 / Metabolic syndrome in Cushing’s syndrome / Neuroendocrinology 92(Suppl 1):96~101
Di Somma C / 2002 / Severe impairment of bone mass and turnover in Cushing’s disease: comparison between childhood-onset and adulthood-onset disease / Clin Endocrinol (Oxf) 56:153~158
Pivonello R / 2010 / Pathophysiology of diabetes mellitus in Cushing’s syndrome / Neuroendocrinology 92(Suppl 1):77~81
Vegiopoulos A / 2007 / Glucocorticoids, metabolism and metabolic diseases / Mol Cell Endocrinol 275:43~61
Mazziotti G / 2011 / Diabetes in Cushing syndrome: basic and clinical aspects / Trends Endocrinol Metab 22:499~506
Di Somma C / 2002 / Severe impairment of bone mass and turnover in Cushing’s disease: comparison between childhood-onset and adulthood-onset disease / Clin Endocrinol (Oxf) 56:153~158
Pivonello R / 2010 / Pathophysiology of diabetes mellitus in Cushing’s syndrome / Neuroendocrinology 92(Suppl 1):77~81
Vegiopoulos A / 2007 / Glucocorticoids, metabolism and metabolic diseases / Mol Cell Endocrinol 275:43~61
Mazziotti G / 2011 / Diabetes in Cushing syndrome: basic and clinical aspects / Trends Endocrinol Metab 22:499~506
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