지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 776 - 785 (10page)
이용수
초록· 키워드
오류제보하기
Background and Objectives: Trapped thrombus in patent foramen ovale (PFO) is a rare complication of pulmonary embolism that may lead to tragic clinical events. The aim of this study was to identify the optimal treatment for different clinical situations in patients with trapped thrombus in a PFO by conducting a literature review. Subjects and Methods: A PubMed database search was conducted from 1991 through 2015, and 194 patients (185 articles) with trapped thrombus in a PFO were identified. Patient characteristics, paradoxical embolic events, and factors affecting 60-day mortality were analyzed retrospectively. Results: Among all patients, 112 (57.7%) were treated with surgery, 28 with thrombolysis, and 54 with anticoagulation alone. Dyspnea (79.4%), chest pain (33.0%), and syncope (17.5%) were the most common presenting symptoms. Pretreatment embolism was found in 37.6% of cases, and stroke (24.7%) was the most common event. Surgery was associated with fewer post-treatment embolic events than were other treatment options (p=0.044). In the multivariate analysis, initial shock or arrest, and thrombolysis were independent predictors of 60-day mortality. Thrombolysis was related with higher 60-day mortality compared with surgery in patients who had no initial shock or arrest. Conclusion: This systematic review showed that surgery was associated with a lower overall incidence of post-treatment embolic events and a lower 60-day mortality in patients with trapped thrombus in a PFO. In patients without initial shock or arrest, thrombolysis was related with a higher 60-day mortality compared with surgery.
목차
등록된 정보가 없습니다.
참고문헌 (14)
참고문헌 신청
Kent DM / 2013 / An index to identify stroke-related vs incidental patent foramen ovale in cryptogenic stroke / Neurology 81:619~625
Hagen PT / 1984 / Incidence and size of patent foramen ovale during the first 10 decades of life: an autopsy study of 965 normal hearts / Mayo Clin Proc 59:17~20
Konstantinides S / 1998 / Patent foramen ovale is an important predictor of adverse outcome in patients with major pulmonary embolism / Circulation 97:1946~1951
Meacham RR 3rd / 1998 / Impending paradoxical embolism / Arch Intern Med 158:438~448
Fauveau E / 2008 / Surgical or medical treatment for thrombus straddling the patent foramen ovale: impending paradoxical embolism? Report of four clinical cases and literature review / Arch Cardiovasc Dis 101:637~644
Hagen PT / 1984 / Incidence and size of patent foramen ovale during the first 10 decades of life: an autopsy study of 965 normal hearts / Mayo Clin Proc 59:17~20
Konstantinides S / 1998 / Patent foramen ovale is an important predictor of adverse outcome in patients with major pulmonary embolism / Circulation 97:1946~1951
Meacham RR 3rd / 1998 / Impending paradoxical embolism / Arch Intern Med 158:438~448
Fauveau E / 2008 / Surgical or medical treatment for thrombus straddling the patent foramen ovale: impending paradoxical embolism? Report of four clinical cases and literature review / Arch Cardiovasc Dis 101:637~644
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