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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 121 - 134 (14page)
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초록· 키워드
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Purpose: Catheter direct thrombolysis (CDT) has been shown to be an effective treatment for deep venous thrombosis. The objective of the review is to improve safety and efficacy of the CDT by using ward based protocol, better able to predict complications and treatment outcome through monitoring of haemostatic parameters and clinical observation during thrombolysis procedure. Materials and Methods: MEDLINE, EMBASE, CENTRAL and Web of Science were searched for all articles on deep venous thrombosis, thrombolysis and correlations of clinical events (bleeding, successful thrombolysis) during thrombolysis with hemostatic parameters to March 2016. The risk of bias in included studies was assessed by Cochrane Collaboration’s tool and Cochrane Risk of Bias Assessment Tool: for Non-Randomized Studies of Interventions. Results: Twenty-four studies were included in the review and we found that improving safety and efficacy of CDT by using ward based protocol depending on eight factors; strict patient selection criteria, types of fibrinolytic drugs, mode of fibrinolytic drug injection, biochemical markers monitoring (fibrinogen, D-dimer, activated partial thromboplastin time, plasminogen activator inhibitor-1), timing of intervention, usage of intermittent pneumatic calf, ward monitoring and thrombolysis imaging assessment (intravascular ultrasound). These factors may help to improve safety and efficacy by reducing total thrombolytic drug dosage and at the same time ensure successful lysis. There is a marked lack of randomized controlled trials discussing the safety and efficacy of catheter direct thrombolysis. Conclusion: CDT can be performed safely and efficiently in clinical ward, providing that careful nursing, biochemical monitoring, proper selection and mode of infusion of fibrinolytic drugs, usage of Intermittent pneumatic calf and adequate thrombolysis imaging assessment are ensured.
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등록된 정보가 없습니다.
참고문헌 (6)
참고문헌 신청
Meissner MH / 2007 / Acute venous disease: venous thrombosis and venous trauma / J Vasc Surg 46(Suppl S):25S~53S
Kearon C / 2008 / Antithrombotic therapy for venous thromboembolic disease: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines / Chest 133(6 Suppl):454S~545S
Arnoldussen C / 2014 / Feasibility of identifying deep vein thrombosis characteristics with contrast enhanced MR-Venography / Phlebology 29(1 Suppl):119~124
Bækgaard N / 2015 / Thrombus age is ideally measured by history or MRV prior to thrombus removal / Phlebology 30(1 Suppl):20~26
Smalling RW. / 1997 / Pharmacological and clinical impact of the unique molecular structure of a new plasminogen activator / Eur Heart J 18(Suppl F):F11~F16
Kearon C / 2008 / Antithrombotic therapy for venous thromboembolic disease: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines / Chest 133(6 Suppl):454S~545S
Arnoldussen C / 2014 / Feasibility of identifying deep vein thrombosis characteristics with contrast enhanced MR-Venography / Phlebology 29(1 Suppl):119~124
Bækgaard N / 2015 / Thrombus age is ideally measured by history or MRV prior to thrombus removal / Phlebology 30(1 Suppl):20~26
Smalling RW. / 1997 / Pharmacological and clinical impact of the unique molecular structure of a new plasminogen activator / Eur Heart J 18(Suppl F):F11~F16
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