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지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Purpose: We tried to identify the factors associated with intracranial hemorrhage (ICH) in patients with acute brain infarction receiving a tissue plasminogen activator. We assumed that ICH is increased if intracranial pressure has been increased in brain infarction patients who underwent IV thrombolysis. In this study, we selected the optic nerve sheath diameter (ONSD) in a way that intracranial pressure (ICP) measurement. ONSD measurements were compared with the occurrence of brain hemorrhage. Methods: This study was a retrospective analysis of data acquired between January 2013 and December 2015. We included 100 acute brain infarction patients who received brain MRI and underwent IV thrombolysis in the emergency department. The ONSD measurements were taken with MRI in the axial view and compared with the occurrence of brain hemorrhage. The factors contributing to ICH in patients with thrombolysis was analyzed by a binary logistic regression analysis. Receiver operating characteristic (ROC) curves were used to find the cut-off value of ONSD that maximized the sum of the sensitivity and specificity. Statistical analysis was performed using SPSS 20.0. Results: The mean ONSD for patients without ICH was 5.50±0.57 mm, and for those with ICH was 5.97±0.54 mm. ONSD in the ICH group were significantly larger than in the non-ICH group (5.50±0.57 versus 5.97±0.54). Conclusion: ONSD in acute brain infarction patients who underwent IV thrombolysis is useful in the assessment of ICH risk.
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참고문헌 (24)
참고문헌 신청
The NINDS t-PA Stroke Study Group / 1997 / Intracerebral hemorrhage after intravenous t-PA therapy for ischemic stroke / Stroke 28:2109~2118
Tanne D / 2002 / Markers of increased risk of intracerebral hemorrhage after intravenous recombinant tissue plasminogen activator therapy for acute ischemic stroke in clinical practice the multicenter rt-PA acute stroke survey / Circulation 105:1679~1685
Derex L / 2005 / Clinical and imaging predictors of intracerebral haemorrhage in stroke patients treated with intravenous tissue plasminogen activator / J Neurol Neurosurg Psychiatry 76:70~75
IMS Study Investigators / 2006 / Hemorrhage in the interventional management of stroke study / Stroke 37:847~851
Selim M / 2002 / Predictors of hemorrhagic transformation after intravenous recombinant tissue plasminogen activator prognostic value of the initial apparent diffusion coefficient and diffusion-weighted lesion volume / Stroke 33:2047~2052
Tanne D / 2002 / Markers of increased risk of intracerebral hemorrhage after intravenous recombinant tissue plasminogen activator therapy for acute ischemic stroke in clinical practice the multicenter rt-PA acute stroke survey / Circulation 105:1679~1685
Derex L / 2005 / Clinical and imaging predictors of intracerebral haemorrhage in stroke patients treated with intravenous tissue plasminogen activator / J Neurol Neurosurg Psychiatry 76:70~75
IMS Study Investigators / 2006 / Hemorrhage in the interventional management of stroke study / Stroke 37:847~851
Selim M / 2002 / Predictors of hemorrhagic transformation after intravenous recombinant tissue plasminogen activator prognostic value of the initial apparent diffusion coefficient and diffusion-weighted lesion volume / Stroke 33:2047~2052
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