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자료유형
학술저널
저자정보
이성종 (가톨릭대학교) Andrew Yang (Johns Hopkins Medical Institutions) T.-C. Wu (Johns Hopkins Medical Institutions) Chien-Fu Hung
저널정보
대한부인종양학회 Journal of Gynecologic Oncology Journal of Gynecologic Oncology Vol.27 No.5
발행연도
2016.1
수록면
1 - 17 (17page)

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Cervical cancer is the fourth most lethal women’s cancer worldwide. Current treatmentsagainst cervical cancer include surgery, radiotherapy, chemotherapy, and anti-angiogenicagents. However, despite the various treatments utilized for the treatment of cervical cancer,its disease burden remains a global issue. Persistent infection of human papillomavirus(HPV) has been identified as an essential step of pathogenesis of cervical cancer and manyother cancers, and nation-wide HPV screening as well as preventative HPV vaccinationprogram have been introduced globally. However, even though the commercially availableprophylactic HPV vaccines, Gardasil (Merck) and Cervarix (GlaxoSmithKline), are effectivein blocking the entry of HPV into the epithelium of cervix through generation of HPVspecificneutralizing antibodies, they cannot eliminate the pre-existing HPV infection. Forthese reason, other immunotherapeutic options against HPV-associated diseases, includingtherapeutic vaccines, have been continuously explored. Therapeutic HPV vaccines enhancecell-mediated immunity targeting HPV E6 and E7 antigens by modulating primarily dendriticcells and cytotoxic T lymphocyte. Our review will cover various therapeutic vaccines indevelopment for the treatment of HPV-associated lesions and cancers. Furthermore, we willdiscuss the potential of immune checkpoint inhibitors that have recently been adopted andtested for their treatment efficacy against HPV-induced cervical cancer.

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