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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Background: The colitis-associated cancer exhibits different characteristics according to sex in the initiation and progression of the tumors. The aim of this study was to investigate the sex-associated difference in the azoxymethane/dextran sulfate sodium (AOM/DSS)-induced colitis-associated cancer model. Methods: The AOM/DSS ICR mouse model was established to compare male with female, and then the severity of colitis-associated carcinogenesis was examined macroscopically and histologically regarding the number, size, and location of tumors. Subsequently, levels of colonic mucosal cytokine, interleukin (IL)-1 and myeloperoxidase (MPO) were assessed. Results: At the 16th week, the tumor multiplicity and the pro-inflammatory factors differed according to sex. The total tumor number was significantly higher in male (P = 0.020) and the number of large tumors (diameter ＞ 2 mm) was higher in male (P = 0.026). In male, the tumors located more in distal colon (P = 0.001). MPO was significantly higher in AOM/DSS-treated male mice compared to the control group (P = 0.003), whereas the corresponding female group showed no significant change (P = 0.086). Colonic IL-1β level significantly increased in AOM/DSS groups compared to control groups both in male and female (male, P = 0.014; female, P = 0.005). It was higher in male group; however, there was no statistical significance (P = 0.226). Conclusions: In AOM/DSS murine model, colitis-associated colon tumorigenesis are induced more severely in male mice than female probably by way of inflammatory mediators such as IL-1 and MPO. The sex-related differences at the animal model of colon cancer suggest the importance of approach to disease with sex-specific medicine in human.
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참고문헌 (50)
참고문헌 신청
Ferlay J / 2010 / Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008 / Int J Cancer 127:2893~2917
정규원 / 2012 / Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2009 / Cancer Research and Treatment 44(1):11~24
Matsuda A / 2014 / Cancer incidence and incidence rates in Japan in 2008: a study of 25 population-based cancer registries for the Monitoring of Cancer Incidence in Japan (MCIJ) project / Jpn J Clin Oncol 44:388~396
Brenner H / 2010 / Sex, age, and birth cohort effects in colorectal neoplasms: a cohort analysis / Ann Intern Med 152:697~703
Ahlquist T / 2008 / Gene methylation profiles of normal mucosa, and benign and malignant colorectal tumors identify early onset markers / Mol Cancer 7:94
정규원 / 2012 / Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2009 / Cancer Research and Treatment 44(1):11~24
Matsuda A / 2014 / Cancer incidence and incidence rates in Japan in 2008: a study of 25 population-based cancer registries for the Monitoring of Cancer Incidence in Japan (MCIJ) project / Jpn J Clin Oncol 44:388~396
Brenner H / 2010 / Sex, age, and birth cohort effects in colorectal neoplasms: a cohort analysis / Ann Intern Med 152:697~703
Ahlquist T / 2008 / Gene methylation profiles of normal mucosa, and benign and malignant colorectal tumors identify early onset markers / Mol Cancer 7:94
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