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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the colon and rectum with intervals of acute exacerbation. Its etiology remains unknown, although recent studies suggest that pro-inflammatory cytokines initiate the inflammatory responses. In this study, we investigated the ameliorative effects of YB-21 (new product containining Lactobacillus plantarum, Barley Bran and Nymphaeaceae) in a dextran sulfate sodium (DSS)-induced colitis in mice. The experimental groups were divided into 6 groups (n = 10) of ICR mice: normal control(NC), DSS-treated(PC, positive control), DSS+latic-L-treated (3×107CFU/ml), DSS+latic-M-treated (3×109CFU/ml), DSS+latic-H-treated (3×1011CFU/ml), and DSS+YB-21-treated. Histological examinations indicated that YB-21 suppressed edema, mucosal damage, and the loss of crypts induced by DSS. Moreover, YB-21 reduced serum level expressions of, tumor necrosis factor-α (TNF-α). These results suggest that YB-21 has an anti-colitic effect by the suppression of intestinal inflammatory responses in DSS-induced colitis in mice.
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참고문헌 (32)
참고문헌 신청
Abraham C / 2009 / Inflammatory bowel disease / N Engl J Med 361(21):2066~2078
안중환 / 2006 / 황련해독탕이 DSS로 유발된 흰쥐의 궤양성 대장염에 미치는 영향 / 대한한의학회지 27(2):182~195
Arjun P / 2012 / Phytochemical analysis and anticancer activity of Nelumbo nucifera extracts / J. Acad. Indus 1:81~85
Baskaran R / 2017 / Neferine from Nelumbo nuci fera modulates oxidative stress and cytokines production during hypoxia in human peripheral blood mononuclear cells / Biomed. Pharmacother 93:730~736
Chung YW / 2007 / Lactobacillus casei prevents the development of dextran sulfate sodium-induced colitis in Toll-like receptor 4 mutant mice / Clin. Exp. Immunol 151:182~189
안중환 / 2006 / 황련해독탕이 DSS로 유발된 흰쥐의 궤양성 대장염에 미치는 영향 / 대한한의학회지 27(2):182~195
Arjun P / 2012 / Phytochemical analysis and anticancer activity of Nelumbo nucifera extracts / J. Acad. Indus 1:81~85
Baskaran R / 2017 / Neferine from Nelumbo nuci fera modulates oxidative stress and cytokines production during hypoxia in human peripheral blood mononuclear cells / Biomed. Pharmacother 93:730~736
Chung YW / 2007 / Lactobacillus casei prevents the development of dextran sulfate sodium-induced colitis in Toll-like receptor 4 mutant mice / Clin. Exp. Immunol 151:182~189
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