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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.12
- 수록면
- 358 - 365 (8page)
이용수
초록· 키워드
오류제보하기
Mesenchymal stem cells (MSCs) have been used experimentally for treating inflammatory disorders, partly owing to their immunosuppressive properties. The goal of the study was to determine whether TLR ligands can enhance the therapeutic efficacy of bone marrow-derived MSCs for the treatment of inflammatory bowel disease. Mice (C57BL6) were administered with 4% dextran sulfate sodium (DSS) in drinking water for 7 days and injected with MSCs on days 1 and 3 following DSS ingestion. Our results demonstrated that among various TLR ligands, MSCs treated with polyinosinic-polycytidylic acid [poly(I:C)], which is a TLR3 ligand, more profoundly induced IDO, which is a therapeutically relevant immunosuppressive factor, without any observable phenotype change in vitro. The poly(I:C)- treated MSCs attenuated the pathologic severity of DSS-induced murine colitis when injected i.p. but not i.v. In summary, preconditioning MSCs with poly(I:C) might improve their efficacy in treating DSS-induced colitis, and this effect at least partly depends on the enhancement of their immunosuppressive activity through increasing their production of IDO.
목차
INTRODUCTION
Materials and Methods
Results
Discussion
REFERENCES
참고문헌 (17)
참고문헌 신청
[학술지(정기간행물)] - Tsagias, N / 2011 / Isolation of mesenchymal stem cells using the total length of umbilical cord for transplantation purposes / Transfus. Med 21 : 253 ~ 261
[학술지(정기간행물)] - Liang, L / 2011 / Human umbilical cord mesenchymal stem cells ameliorate mice trinitrobenzene sulfonic acid (TNBS)-induced colitis / Cell Transplant 20 : 1395 ~ 1408
[학술지(정기간행물)] - Chamberlain, G / 2007 / Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing / Stem Cells 25 : 2739 ~ 2749
[학술지(정기간행물)] - DelaRosa, O / 2010 / Modulation of adult mesenchymal stem cells activity by toll-like receptors:implications on therapeutic potential / Mediators Inflamm 2010 : 865601 ~
[학술지(정기간행물)] - English, K / 2007 / IFN-gamma and TNF-alpha differentially regulate immunomodulation by murine mesenchymal stem cells / Immunol. Lett 110 : 91 ~ 100
[학술지(정기간행물)] - Liang, L / 2011 / Human umbilical cord mesenchymal stem cells ameliorate mice trinitrobenzene sulfonic acid (TNBS)-induced colitis / Cell Transplant 20 : 1395 ~ 1408
[학술지(정기간행물)] - Chamberlain, G / 2007 / Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing / Stem Cells 25 : 2739 ~ 2749
[학술지(정기간행물)] - DelaRosa, O / 2010 / Modulation of adult mesenchymal stem cells activity by toll-like receptors:implications on therapeutic potential / Mediators Inflamm 2010 : 865601 ~
[학술지(정기간행물)] - English, K / 2007 / IFN-gamma and TNF-alpha differentially regulate immunomodulation by murine mesenchymal stem cells / Immunol. Lett 110 : 91 ~ 100
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UCI(KEPA) : I410-ECN-0101-2017-517-001848992