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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 251 - 260 (10page)
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초록· 키워드
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In this study, porous scaffolds were produced by a thermal crosslinking of polycaprolactone diacrylate in the presence of hydroxyapatite (HA) and particulate leaching technique with sodium chloride as the water soluble porogen for bone tissue engineering applications. The prepared scaffolds were characterized using techniques such as Field Emission Scanning Electron Microscopy, Differential Scanning Calorimetry, and Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy. Moreover, dynamic mechanical properties were investigated using Dynamic Mechanical Thermal Analysis. The obtained scaffolds present a porous structure with interconnected pores and porosity around 73%. It was found that the incorporation of HA particles to polycaprolactone (PCL) matrix resulted in an increased crystallinity. Moreover, both the storage modulus (E’) and glass transition temperature (Tg) increased, while the loss factor (tan δ) decreased due to the hindrance of the HA particles to the mobility of polymer segments. Cytocompatability of the scaffolds was assessed by MTT assay and cell attachment studies. Osteoconductivity of the scaffolds was investigated with cells alkaline phosphatase extraction. The levels of alkaline phosphatase activity were found to be higher for PCL/HA network scaffold than for PCL network scaffold. In addition, cytocompatibility of the PCL/HA network scaffold indicated no toxicity, and cells were attached and spread to the scaffold walls.
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참고문헌 (35)
참고문헌 신청
Soheilmoghaddam M / 2014 / Regenerated cellulose/β-cyclodextrin scaffold prepared using ionic liquid / Mater Lett 135:210~213
이세환 / 2014 / Analysis of Degradation Rate for Dimensionless Surface Area of Well-Interconnected PCL Scaffold Via in-vitro Accelerated Degradation Experiment / 조직공학과 재생의학 11(6):446~452
이승환 / 2014 / Osteogenic Activity of Chitosan-based Hybrid Scaffold Prepared by Polyelectrolyte Complex Formation with Alginate / 조직공학과 재생의학 11(2):106~112
García Cruz DM / 2009 / Physical interactions in macroporous scaffolds based on poly(ε-caprolactone)/chitosan semi-interpenetrating polymer networks / Polymer 50:2058~2064
Amirreza Rezaei / 2012 / Development of Hydroxyapatite Nanorods–Polycaprolactone Composites and Scaffolds Derived from a Novel In-Situ Sol-Gel Process / 조직공학과 재생의학 9(6):295~303
이세환 / 2014 / Analysis of Degradation Rate for Dimensionless Surface Area of Well-Interconnected PCL Scaffold Via in-vitro Accelerated Degradation Experiment / 조직공학과 재생의학 11(6):446~452
이승환 / 2014 / Osteogenic Activity of Chitosan-based Hybrid Scaffold Prepared by Polyelectrolyte Complex Formation with Alginate / 조직공학과 재생의학 11(2):106~112
García Cruz DM / 2009 / Physical interactions in macroporous scaffolds based on poly(ε-caprolactone)/chitosan semi-interpenetrating polymer networks / Polymer 50:2058~2064
Amirreza Rezaei / 2012 / Development of Hydroxyapatite Nanorods–Polycaprolactone Composites and Scaffolds Derived from a Novel In-Situ Sol-Gel Process / 조직공학과 재생의학 9(6):295~303
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