지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 415 - 425 (11page)
이용수
초록· 키워드
오류제보하기
BACKGROUND: Several types of three-dimensional (3D)-printed tracheal scaffolds have been reported. Nonetheless, most of these studies concentrated only on application of the final product to an in vivo animal study and could not show the effects of various 3D printing methods, materials, or parameters for creation of an optimal 3D-printed tracheal scaffold. The purpose of this study was to characterize polycaprolactone (PCL) tracheal scaffolds 3D-printed by the 4-axis fused deposition modeling (FDM) method and determine the differences in the scaffold depending on the additive manufacturing method. METHODS: The standard 3D trachea model for FDM was applied to a 4-axis FDM scaffold and conventional FDM scaffold. The scaffold morphology, mechanical properties, porosity, and cytotoxicity were evaluated. Scaffolds were implanted into a 7 9 10-mm artificial tracheal defect in rabbits. Four and 8 weeks after the operation, the reconstructed sites were evaluated by bronchoscopic, radiological, and histological analyses. RESULTS: The 4-axis FDM provided greater dimensional accuracy and was significantly closer to CAD software-based designs with a predefined pore size and pore interconnectivity as compared to the conventional scaffold. The 4-axis tracheal scaffold showed superior mechanical properties. CONCLUSION: We suggest that the 4-axis FDM process is more suitable for the development of an accurate and mechanically superior trachea scaffold.
목차
등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
Ott LM / 2016 / Mechanical evaluation of gradient electrospun scaffolds with 3D printed ring reinforcements for tracheal defect repair / Biomed Mater 11:25020
Lee DY / 2016 / Segmental tracheal reconstruction by 3D-printed scaffold: pivotal role of asymmetrically porous membrane / Laryngoscope 126:E304~E309
Chang JW / 2014 / Tissue-engineered tracheal reconstruction using three-dimensionally printed artificial tracheal graft: preliminary report / Artif Organs 38:E95~E105
Atala A / 2015 / Essentials of 3D biofabrication and translation / Elsevier Inc. :43~59
Jung SY / 2016 / 3D printed polyurethane prosthesis for partial tracheal reconstruction: a pilot animal study / Biofabrication 8:45015
Lee DY / 2016 / Segmental tracheal reconstruction by 3D-printed scaffold: pivotal role of asymmetrically porous membrane / Laryngoscope 126:E304~E309
Chang JW / 2014 / Tissue-engineered tracheal reconstruction using three-dimensionally printed artificial tracheal graft: preliminary report / Artif Organs 38:E95~E105
Atala A / 2015 / Essentials of 3D biofabrication and translation / Elsevier Inc. :43~59
Jung SY / 2016 / 3D printed polyurethane prosthesis for partial tracheal reconstruction: a pilot animal study / Biofabrication 8:45015
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