Ototoxicity: A Challenge in Diagnosis and Treatment

Purushothaman Ganesan; Jason Schmiedge; Vinaya Manchaiah; Simham Swapna; Subhashini Dhandayutham; Purushothaman Pavanjur Kothandaraman

추천

검색

자료유형: 학술저널

저자정보: Purushothaman Ganesan (Wall Street Audiology Group Inc.) Jason Schmiedge (Wall Street Audiology Group Inc.) Vinaya Manchaiah (Lamar University) Simham Swapna (Hindu Mission Hospital) Subhashini Dhandayutham (Madras ENT Research Foundation) Purushothaman Pavanjur Kothandaraman (SRM Medical College Hospital and Research Centre)

저널정보: 대한청각학회 Journal of Audiology & Otology Journal of Audiology & Otology Vol.22 No.2

발행연도: 2018.1

수록면: 59 - 68 (10page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Ototoxicity is the pharmacological adverse reaction affecting the inner ear or auditory nerve,characterized by cochlear or vestibular dysfunction. The panorama of drug-induced hearingloss has widened over last few decades. Although ototoxic medications play an imperativerole in modern medicine, they have the capacity to cause harm and lead to significant morbidity. Evidence has shown early detection of toxicity through prospective ototoxicity monitoringallows for consideration of treatment modifications to minimize or prevent permanenthearing loss and balance impairment. Although many ototoxicity monitoring protocols exist,their practicality is questionable due to several factors. Even though the existing protocolshave proven to be effective, certain lacunae in practice have been encountered due to discrepanciesamong recommended protocols. Implementation of these protocols is mostlyheld back due to the incapacitated status of the patient. The choice of early ototoxicity identificationtechniques is still debatable due to variables such as high degree of sensitivity,specificity and reliability, less time consumption and less labour-intensive to the patient. Hence, the diagnosis and effective treatment of ototoxicity is challenging, even today. A stringentprotocol with more practicality encompassing all elements aimed at profiling the effectsof ototoxicity is greatly needed. This review describes an efficient application of ototoxicitymonitoring and treatment protocol as an attempt to reduce the challenges in diagnosis andmanagement of ototoxicity.

참고문헌 (67)

참고문헌 신청

Naunton RF / 1959 / The ototoxicity of Kanamycin sulfate in the presence of compromised renal function / AMA Arch Otolaryngol 69:398~399

Arslan E / 1999 / Global problem of drug-induced hearing loss / Ann N Y Acad Sci 884:1~14

Cianfrone G / 2011 / Pharmacological drugs inducing ototoxicity, vestibular symptoms and tinnitus: a reasoned and updated guide / Eur Rev Med Pharmacol Sci 15:601~636

Knight KR / 2005 / Ototoxicity in children receiving platinum chemotherapy: underestimating a commonly occurring toxicity that may influence academic and social development / J Clin Oncol 23:8588~8596

Konrad-Martin D / 2005 / Audiological monitoring of patients receiving ototoxic drugs / Perspect Hear Hear Disord Res Res Diagn 9:17~22

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!