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자료유형
학술저널
저자정보
김태원 (가톨릭대학교 의과대학 신경과학교실) 구자성 (가톨릭대학교) 송인욱 (가톨릭대학교) 한시령 (가톨릭대학교) 정성우 (가톨릭대학교) 김승훈 (가톨릭대학교) 이광수 (가톨릭대학교)
저널정보
대한신경집중치료학회 Journal of Neurocritical Care Journal of Neurocritical Care Vol.11 No.1
발행연도
2018.1
수록면
23 - 31 (9page)

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Background: A subanalysis study of the ENGAGE AF-TIMI 48 trial showed that cardiac troponin I, N-terminal proB-type natriuretic peptide, and D-dimer, were powerful predictors of cerebrovascular adverse events. We aimed to evaluate D-dimer and cardiac troponin I levels during the acute period of ischemic stroke in anticoagulation-naïve patients with nonvalvular atrial fibrillation (NVAF) and also studied the association between these biomarkers and stroke severity. Methods: Consecutive anticoagulation-naïve patients with acute ischemic stroke due to NVAF were enrolled within two days after each stroke event, and all patients were stratified into either moderate-to-severe or mild neurologic deficit groups using the National Institutes of Health Stroke Scale (NIHSS) at admission. Results: A total of 98 patients were enrolled in this study. The median value for the D-dimer was above the upper limit of the normal reference range, but the troponin I value was within the normal range for all patients. After adjusting for CHA2DS2-VASc risk factors, the logtransformed values for D-dimer were positively correlated with an increasing NIHSS score (r=0.233; P =0.051). In the multivariate logistic analysis, the log-transformed D-dimer was positively associated with more severe strokes (odds ratio, 30.1; 95% confidence interval [CI], 1.9-486.2 and 29.7; 95% CI, 2.0-430.8 in the upper two quartiles respectively). The logtransformed values for troponin I did not correlate with the NIHSS score. Conclusion: D-dimer levels were higher and an independent risk factor for severe stroke in anticoagulation-naïve patients with NVAF related stroke. In contrast, troponin I levels were normal and were not associated with stroke severity.

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