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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 394 - 399 (6page)
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Purpose: The purposes our study was to find out any histologic factors associated with negative conversion of axillary lymph node (ALN) after neoadjuvant chemotherapy (NAC). We also evaluated the association between the decrease in size of primary breast tumor and negative conversion of ALN. Methods: From January 2012 to November 2014, we included 133 breast cancer patients who underwent NAC and who had ALN metastases which were confirmed on fine-needle aspiration or core needle biopsy at initial diagnosis. All 133 patients underwent initial magnetic resonance imaging (MRI) at the time of diagnosis and preoperative MRI after completion of NAC. We measured the longest dimension of primary breast cancer on MRI. Results: Of 133 patients, 39 patients (29%) showed negative conversion of ALN and of these 39 patients, 25 patients (64%) showed pathologic complete remission of primary breast. On univariate analysis, mean percent decrease in longest dimension, estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 status and histologic grade were significantly associated with the ALN status after NAC (p<0.001, p=0.001, p< 0.001, p=0.001, p=0.002, respectively). On multivariate logistic regression analysis, percent decrease in longest dimension (odds ratio, 1.026; 95% confidence interval [CI], 1.009–1.044) and histologic grade (odds ratio, 3.964; 95% CI, 1.151–13.657) were identified as being independently associated with the ALN status after NAC. The area under the receiver operating characteristic curve was 0.835 with the best cutoff value of 80% decrease in longest dimension. Combination of high histologic grade and more than 80% decrease in longest dimension showed 64% sensitivity and 92% specificity. Conclusion: High histologic grade and more than 80% decrease in primary tumor dimension were associated with negative conversion of ALN after NAC.
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참고문헌 (27)
참고문헌 신청
Mansel RE / 2006 / Randomized multicenter trial of sentinel node biopsy versus standard axillary treatment in operable breast cancer : the ALMANAC Trial / J Natl Cancer Inst 98:599~609
Cox CE / 1998 / Sentinel lymphadenectomy: a safe answer to less axillary surgery? / Recent Results Cancer Res 152:170~179
Lucci A / 2007 / Surgical complications associated with sentinel lymph node dissection(SLND)plus axillary lymph node dissection compared with SLND alone in the American College of Surgeons Oncology Group Trial Z0011 / J Clin Oncol 25:3657~3663
Ju NR / 2013 / Patient and tumor characteristics associated with breast cancer recurrence after complete pathological response to neoadjuvant chemotherapy / Breast Cancer Res Treat 137:195~201
Gonzalez-Angulo AM / 2005 / Factors predictive of distant metastases in patients with breast cancer who have a pathologic complete response after neoadjuvant chemotherapy / J Clin Oncol 23:7098~7104
Cox CE / 1998 / Sentinel lymphadenectomy: a safe answer to less axillary surgery? / Recent Results Cancer Res 152:170~179
Lucci A / 2007 / Surgical complications associated with sentinel lymph node dissection(SLND)plus axillary lymph node dissection compared with SLND alone in the American College of Surgeons Oncology Group Trial Z0011 / J Clin Oncol 25:3657~3663
Ju NR / 2013 / Patient and tumor characteristics associated with breast cancer recurrence after complete pathological response to neoadjuvant chemotherapy / Breast Cancer Res Treat 137:195~201
Gonzalez-Angulo AM / 2005 / Factors predictive of distant metastases in patients with breast cancer who have a pathologic complete response after neoadjuvant chemotherapy / J Clin Oncol 23:7098~7104
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