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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Purpose: We evaluated the blood urea nitrogen (BUN)/albumin (B/A) ratio in patients with acute cholangitis to determine the prognostic significance of the B/A ratio as a marker of early mortality in critically ill patients with acute cholangitis. Methods: We retrospectively analyzed medical records in two emergency departments (ED) and screened eligible adult patients who were admitted to the ED with acute cholangitis. The B/A ratio was evaluated as the BUN value divided by albumin level on each hospital day. The clinical outcome was mortality after 28 days. Results: A total of 461 patients with acute cholangitis were included in this study. Multivariate Cox proportional hazard models showed that higher B/A ratio on ED admission (day 1) (Hazard Ratio (HR): 1.182; 95% Confidence Interval (CI): 1.076-1.298, p<0.001) and day 4 (HR: 1.192; 95% CI: 1.019-1.395, p=0.028) were independent risk factors for mortality at 28 days. Our study showed that the increased 28-day mortality was associated with a B/A ratio >6.83 on day 1 (HR: 4.065; 95% CI: 4.123-43.737, p<0.001) and a higher B/A ratio (>6.26) on day 4 (HR: 7.16; 95% CI: 1.412- 36.333, p=0.018) in patients with acute cholangitis. Conclusion: The ratio of BUN to albumin on ED admission is a promising prognostic marker of 28-day mortality in patients with acute cholangitis.
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참고문헌 (26)
참고문헌 신청
Kimura Y / 2007 / Definitions, pathophysiology, and epidemiology of acute cholangitis and cholecystitis : Tokyo Guidelines / J Hepatobiliary Pancreat Surg 14:15~26
Gigot JF / 1989 / Multivariate analysis of risk factors / Ann Surg 209:435~438
Lee DW / 1997 / Biliary infection / Baillieres Clin Gastroenterol 11:707~724
Kawada N / 1996 / Pathophysiology of acute obstructive cholangitis / J Hep Bil Pancr Surg 3:4~8
Lai EC / 1992 / Endoscopic biliary drainage for severe acute cholangitis / N Engl J Med 326:1582~1586
Gigot JF / 1989 / Multivariate analysis of risk factors / Ann Surg 209:435~438
Lee DW / 1997 / Biliary infection / Baillieres Clin Gastroenterol 11:707~724
Kawada N / 1996 / Pathophysiology of acute obstructive cholangitis / J Hep Bil Pancr Surg 3:4~8
Lai EC / 1992 / Endoscopic biliary drainage for severe acute cholangitis / N Engl J Med 326:1582~1586
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