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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Extracts from Aloe vera leaves, Aloe arborescens leaves, Aloe vera callus, Portulaca oleracea and cacao (Theobromacacao L.) bean husk (CBH) were prepared using acetone, chloroform, ethanol, hexane, and water. Solventextracts of Aloe vera leaf had very high antioxidant activities showing IC50 values in the ranges of 0.02-0.17 mg/mL, and had the highest total phenolic and flavonoid content among the tested samples. We hypothesized that Aloevera leaf and CBH extracts might possess considerable in vitro anti-glycation activities. Indeed, these extractsstrongly inhibited the formation of advanced glycation end-products from RNase in the presence of ribose. The chloroformextract of Aloe vera leaf showed the strongest inhibition of AGE formation (99.9%), followed by the 95%acetone extract (92.8%) at a concentration of 1 mg/mL, exhibiting higher anti-glycation activities than those of AGand rutin (73.4% and 96.1% at 1 mg/mL, respectively). The anti-glycation activity of all extracts was correlated positivelywith their total contents of phenolics and flavonoids. We conclude that Aloe vera leaf extracts and their constituentsmay be used as anti-glycation agents.
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참고문헌 (35)
참고문헌 신청
Ahmad MS. / 2007 / Aged garlic extract and S-allyl cysteine prevent formation of advanced glycation endproducts / Eur. J. Pharmacol 561:32~38
Ardestani A. / 2007 / Cyperus rotundus suppresses AGE formation and protein oxidation in a model fructosemediated protein glycoxidation / Int. J. Biol. Macromol 41:572~578
Ardestani A. / 2007 / Inhibitory effects of ethyl acetate extract of Teucrium polium on in vitro protein glycoxidation / Food Chem. Toxicol 45:2402~2411
Bonnefont-Rousselot D. / 2002 / Glucose and reactive oxygen species / Curr. Opin. Clin. Nutr. Metab, Care 5:561~568
Bousova I. / 2005 / Evaluation of in vitro effects of natural substances of plant origin using a model of protein glycosylation / J. Pharm. Biomed. Anal 37:957~962
Ardestani A. / 2007 / Cyperus rotundus suppresses AGE formation and protein oxidation in a model fructosemediated protein glycoxidation / Int. J. Biol. Macromol 41:572~578
Ardestani A. / 2007 / Inhibitory effects of ethyl acetate extract of Teucrium polium on in vitro protein glycoxidation / Food Chem. Toxicol 45:2402~2411
Bonnefont-Rousselot D. / 2002 / Glucose and reactive oxygen species / Curr. Opin. Clin. Nutr. Metab, Care 5:561~568
Bousova I. / 2005 / Evaluation of in vitro effects of natural substances of plant origin using a model of protein glycosylation / J. Pharm. Biomed. Anal 37:957~962
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