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학술저널
저자정보
Ginseng extract and ginsenosides improve neurologi (Shanghai University of Traditional Chinese Medicine) Gan Li (Shanghai University of Traditional Chinese Medicine) Long-yun Zhou (Jiangsu Provincial People"s Hospital) Yong-jia Song (Shanghai University of Traditional Chinese Medicine) Xu-qing Chen (Affiliated Hospital of Nanjing University of Chinese Medicine) Yong-jun Wang (Shanghai University of Traditional Chinese Medicine) Min Yao (Shanghai University of Traditional Chinese Medicine) Xue-jun Cui (Shanghai University of Traditional Chinese Medicine)
저널정보
고려인삼학회 Journal of Ginseng Research Journal of Ginseng Research Vol.46 No.1
발행연도
2022.1
수록면
11 - 22 (12page)

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Spinal cord injury (SCI) is defined as damage to the spinal cord that temporarily or permanently changes its function. There is no definite treatment established for neurological complete injury patients. This study investigated the effect of ginseng extract and ginsenosides on neurological recovery and antioxidant efficacies in rat models following SCI and explore the appropriate dosage. Searches were done on PubMed, Embase, and Chinese databases, and animal studies matches the inclusion criteria were selected. Pair-wise meta-analysis and subgroup analysis were performed. Ten studies were included, and the overall methodological qualities were low quality. The result showed ginseng extract and ginsenosides significantly improve neurological function, through the Basso, Beattie, and Bresnahan (BBB) locomotor rating scale (pooled MD = 4.40; 95% CI = 3.92 to 4.88; p < 0.00001), significantly decrease malondialdehyde (MDA) (n = 290; pooled MD = -2.19; 95% CI = -3.16 to -1.22; p < 0.0001) and increase superoxide dismutase (SOD) levels (n = 290; pooled MD = 2.14; 95% CI = 1.45 to 2.83; p < 0.00001). Both low (<25 mg/kg) and high dosage (≥25 mg/kg) showed significant improvement in the motor function recovery in SCI rats. Collectively, this review suggests ginseng extract and ginsenosides has a protective effect on SCI, with good safety and a clear mechanism of action and may be suitable for future clinical trials and applications.

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ABSTRACT
1. Introduction
2. Methods
3. Results
4. Discussion
5. Conclusion
References

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