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논문 기본 정보

자료유형
학술저널
저자정보
Farzin Sarkarat (Oral and Maxillofacial Surgery Department; Head Craniomaxillofacial Research Center Dental Faculty) Alireza Modarresi (Oral and Maxillofacial Surgery Department and Craniomaxillofacial Research Center Dental Faculty Te) Arefeh Riyahi (raniomaxillofacial Research Center Dental Faculty Tehran Medical Sciences University Islamic Azad U) Pejman Mortazavi (Department of Pathology Faculty of Veterinary Medicine Science and Research Branch Islamic Azad Uni) Fatemeh Tabandeh (National Institute of Genetic Engineering and Biotechnology Tehran Iran) Vahid Rakhshan (Department of Dental Anatomy Tehran Islamic Azad University of Medical Sciences Dental Branch Tehra)
저널정보
대한악안면성형재건외과학회 Maxillofacial Plastic Reconstructive Surgery Maxillofacial Plastic Reconstructive Surgery 제44권
발행연도
2022.1
수록면
1 - 13 (13page)
DOI
https://doi.org/10.1186/s40902-022-00337-7

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AbstractIntroduction: There is no study on the effectiveness of hyaluronic acid (HA) placement either with or withoutabsorbable collagen sponge (ACS) in reducing or preventing bisphosphonate-related osteonecrosis of the jaws(BRONJ). This preliminary animal study examined the efficacy of this clinically important treatment.Methods: For simulating BRONJ, zoledronic acid was administered to 40 rats for 5 weeks. Two weeks later, a rightfirst molar was extracted from each rat. The rats were randomized into four groups of socket treatments: control(empty extraction socket) or with sockets filled with ACS, HA, or HA+ACS (n=4×10). After 2 weeks, 5 rats in eachgroup were sacrificed and subjected to histopathologic and histomorphometric evaluation. Eight weeks postsurgically,the rest of rats were euthanized and histologically examined. The Kruskal-Wallis test was used to comparethe four treatments at each time point (α=0.05).

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